Recent Progress in Metal-Based Nanoparticles Mediated Photodynamic Therapy

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Jingyao SunZhaogang Yang

Abstract

Photodynamic therapy (PDT) is able to non-invasively treat and diagnose various cancers and nonmalignant diseases by combining light, oxygen, and photosensitizers (PSs). However, the application of PDT is hindered by poor water solubility and limited light-penetration depth of the currently available photosensitizers (PSs). Water solubility of PSs is crucial for designing pharmaceutical formulation and administration routes. Wavelength of light source at visible range normally has therapeutic depth less than 1 mm. In this review, focus is on the recent research progress of metal-based nanoparticles being applied in PDT. The potential toxicity of these nanoscales and future directions are further discussed.

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May 9, 2019·Advanced Healthcare Materials·Minhuan LanPengfei Wang
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Methods Mentioned

BETA
fluorescence imaging
electron paramagnetic resonance
surface plasmon resonance
electron spin resonance
biosensor

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