Recent progress in NMR spectroscopy: toward the study of intrinsically disordered proteins of increasing size and complexity

IUBMB Life
Isabella C Felli, Roberta Pierattelli

Abstract

Thanks to recent fast progress, NMR is now in a strategic position to provide unique atomic resolution information on a variety of different biological macromolecules in different conditions (solution, solid state, in-cell). We would like here to present recent developments that enable to focus on intrinsically disordered proteins (IDPs) or intrinsically disordered regions (IDRs) of proteins of increasing size and complexity. They have attracted the attention of the scientific community challenging well accepted ideas and concepts and demanding an expansion of the structure function paradigm.

References

Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·J R TolmanJ H Prestegard
Nov 18, 1998·Current Opinion in Structural Biology·V Dötsch, G Wagner
Nov 5, 1999·Journal of Molecular Biology·P E Wright, H J Dyson
May 31, 2001·Journal of Molecular Graphics & Modelling·A K DunkerZ Obradovic
Feb 13, 2002·Current Opinion in Structural Biology·H Jane Dyson, Peter E Wright
Oct 9, 2002·Trends in Biochemical Sciences·Peter Tompa
Oct 24, 2002·Journal of the American Chemical Society·Konstantin PervushinAlexander Eletsky
Jan 30, 2003·Journal of the American Chemical Society·Seho Kim, Thomas Szyperski
Mar 26, 2003·Journal of Biomolecular NMR·Haiyan ZhangDavid S Wishart
Aug 13, 2003·Journal of Biomolecular NMR·Vladislav Yu OrekhovMartin Billeter
Dec 20, 2003·Nature·Christopher M Dobson
Mar 12, 2004·Journal of the American Chemical Society·Kresten Lindorff-LarsenMichele Vendruscolo
Apr 16, 2005·Angewandte Chemie·Wolfgang BermelPaul R Vasos
Jun 2, 2005·Journal of the American Chemical Society·Paul Schanda, Bernhard Brutscher
Aug 4, 2005·Chembiochem : a European Journal of Chemical Biology·Sina ReckelVolker Dötsch
Oct 27, 2005·Journal of Magnetic Resonance·Michaël Deschamps, Iain D Campbell
Nov 16, 2005·Proteins·Véronique Receveur-BréchotSonia Longhi
Dec 22, 2005·Journal of the American Chemical Society·Pau BernadóMartin Blackledge
Feb 21, 2006·Journal of Magnetic Resonance·Krzysztof KazimierczukIgor Zhukov
Jul 13, 2006·Journal of the American Chemical Society·Paul SchandaBernhard Brutscher
Oct 3, 2006·Journal of Biomolecular NMR·Ivano BertiniGeorgios A Spyroulias
Jan 26, 2007·Current Opinion in Structural Biology·Tanja Mittag, Julie D Forman-Kay
May 31, 2007·Proceedings of the National Academy of Sciences of the United States of America·Andrea CavalliMichele Vendruscolo
Dec 7, 2007·Trends in Biochemical Sciences·Peter Tompa, Monika Fuxreiter
Apr 9, 2008·Proceedings of the National Academy of Sciences of the United States of America·Mark WellsAlan R Fersht
Dec 5, 2008·Journal of the American Chemical Society·Veronika CsizmokIvano Bertini
Mar 25, 2009·Journal of Magnetic Resonance·Wolfgang BermelPeter Tompa
May 13, 2009·Journal of the American Chemical Society·Shang-Te Danny HsuChristopher M Dobson
May 23, 2009·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Isabella C Felli, Bernhard Brutscher
Oct 3, 2009·Journal of the American Chemical Society·Wolfgang BermelRoberta Pierattelli
Jun 23, 2010·Journal of the American Chemical Society·Lukasz SkoraMarkus Zweckstetter
Aug 7, 2010·Journal of the American Chemical Society·Rhagavendran L NarayananMarkus Zweckstetter
Aug 31, 2010·Current Opinion in Structural Biology·Yutaka Ito, Philipp Selenko
Sep 9, 2010·Journal of the American Chemical Society·Ivano BertiniDmitri I Svergun
Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Lucia BanciKostas Tokatlidis
Feb 26, 2011·Angewandte Chemie·Ivano BertiniRoberta Pierattelli
Mar 23, 2011·Journal of Biomolecular NMR·Jiří NováčekVladimír Sklenář
Jun 15, 2011·Proceedings of the National Academy of Sciences of the United States of America·Ivano BertiniPaola Turano

❮ Previous
Next ❯

Citations

Jan 15, 2013·Journal of Biomolecular NMR·Wolfgang BermelSoraya Serrano
Apr 29, 2014·Journal of Biomolecular NMR·Carolina FontanaGöran Widmalm
Aug 1, 2014·Nature Protocols·Isabella C FelliRoberta Pierattelli
Sep 7, 2013·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Simone KosolPeter Tompa
Nov 10, 2015·Expert Opinion on Drug Discovery·Susmitha Ambadipudi, Markus Zweckstetter
Jan 21, 2016·Biophysical Journal·Alessandro PiaiRoberta Pierattelli
Mar 25, 2015·Scientific Reports·Jacqueline D CobbertAlexander Shekhtman
Oct 11, 2012·Protein Science : a Publication of the Protein Society·Felicia L V GrayTomasz Cierpicki
Oct 13, 2012·Chembiochem : a European Journal of Chemical Biology·Wolfgang BermelRoberta Pierattelli
Feb 3, 2015·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Nishit GoradiaRamadurai Ramachandran
Apr 29, 2015·Progress in Nuclear Magnetic Resonance Spectroscopy·Klaus Zangger
Mar 25, 2014·Journal of Magnetic Resonance·Isabella C Felli, Roberta Pierattelli
Feb 12, 2015·Progress in Nuclear Magnetic Resonance Spectroscopy·Isabella C Felli, Roberta Pierattelli
Mar 30, 2016·Annual Review of Physical Chemistry·Mike Reppert, Andrei Tokmakoff
Dec 3, 2016·Nucleic Acids Research·Damiano PiovesanSilvio C E Tosatto
Feb 6, 2018·Journal of Biomolecular NMR·Jakob Toudahl Nielsen, Frans A A Mulder
Jun 20, 2019·Chemical Communications : Chem Comm·Sujeesh SukumaranHanudatta S Atreya
Mar 28, 2019·Scientific Reports·Jakob T Nielsen, Frans A A Mulder
Aug 30, 2019·International Journal of Molecular Sciences·Emeka Nwanochie, Vladimir N Uversky
Mar 2, 2015·Intrinsically Disordered Proteins·Magnus Kjaergaard
Nov 15, 2020·Biomolecules·Maria Grazia MurraliRoberta Pierattelli
Jun 20, 2021·Journal of Biomolecular NMR·Jakob Toudahl Nielsen, Frans A A Mulder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved