PMID: 15374441Mar 1, 1991Paper

Recent progress in testing the longevity determinant and dysdifferentiation hypotheses of aging

Archives of Gerontology and Geriatrics
R G Cutler

Abstract

An overview of the longevity determinant and dysdifferentiation hypotheses is presented, highlighting some of the major postulates and predictions. Results of recent experiments testing these hypotheses are discussed, including the search for specific longevity determinant genes and evidence that cancer and aging may have common causative mechanisms of action and control. Regulation of oxidative stress is considered a potential longevity determinant mechanism and methods and results testing this prediction are reviewed. Possibility of enhancing protective mechanisms against oxidative stress is discussed by way of intervention of central regulatory mechanisms of antioxidants using the cyclase-arachidonic acidcyclooxygenase (GAC model).

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Citations

Feb 1, 1993·Aging : Clinical and Experimental Research·R S Sohal
Mar 13, 2009·Archives of Pharmacal Research·Do Young KwonYoung Chul Kim
Jul 8, 2010·Archives of Pharmacal Research·Sun Ju KimYoung Chul Kim
Sep 29, 2011·Journal of Physiology and Biochemistry·Przemysław SosnowskiRafał Jastak
Jan 1, 1995·Experimental Gerontology·O ToussaintJ Remacle
Mar 1, 1993·Free Radical Biology & Medicine·G CaoR G Cutler
Mar 15, 2003·Clinical Chemistry and Laboratory Medicine : CCLM·Giancarlo BalerciaFrancesco Regoli
Jun 13, 2009·Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics·Sataro Goto
Sep 24, 2005·Stem Cells·Dan ConstantinescuAntonei B Csoka
Jan 12, 2021·Oxidative Medicine and Cellular Longevity·Mario F MuñozAntonio Ayala
Jan 1, 1994·Archives of Gerontology and Geriatrics·C TortorellaS Antonaci

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