Recent progress in the development of near-infrared organic photothermal and photodynamic nanotherapeutics

Biomaterials Science
Houjuan ZhuKanyi Pu

Abstract

Phototherapies including photothermal therapy (PTT) and photodynamic therapy (PDT) have gained considerable attention due to their high tumor ablation efficiency, excellent spatial resolution and minimal side effects on normal tissue. In contrast to inorganic nanoparticles, near-infrared (NIR) absorbing organic nanoparticles bypass the issue of metal-ion induced toxicity and thus are generally considered to be more biocompatible. Moreover, with the guidance of different kinds of imaging methods, the efficacy of cancer phototherapy based on organic nanoparticles has shown to be optimizable. In this review, we summarize the synthesis and application of NIR-absorbing organic nanoparticles as phototherapeutic nanoagents for cancer phototherapy. The chemistry, optical properties and therapeutic efficacies of organic nanoparticles are firstly described. Their phototherapy applications are then surveyed in terms of therapeutic modalities, which include PTT, PDT and PTT/PDT combined therapy. Finally, the present challenges and potential of imaging guided PTT/PDT are discussed.

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Citations

Jul 26, 2018·Future Medicinal Chemistry·Theodora ChatzisideriVasiliki Sarli
Sep 28, 2018·Chemical Society Reviews·Yijing LiuXiaoyuan Chen
Dec 5, 2019·Nanoscale·Houjuan ZhuDavid Tai Leong
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Feb 6, 2020·Biotechnology Journal·Yucong SongZhigang Xie
Mar 4, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xue ZhangShiping Yang
Mar 5, 2020·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Wonbong LimHoon Hyun
Mar 27, 2020·Pharmaceutics·Yanlong YinQian Yang
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Methods Mentioned

BETA
xenografts
xenograft
imaging techniques
fluorescence resonance
X-ray
fluorescence imaging
biosensor
fluorescence
FRET
light harvesting

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