Recent Progress in the Development of Microfluidic Vascular Models

Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry
Kae Sato, Kiichi Sato

Abstract

The blood vessel is part of the circulatory system, and systemic circulation provides the blood supply to all tissues. Arteries are pathways through which the blood is carried, and the capillaries have a key role in material exchange to maintain the tissue environment. Blood vessels have structures appropriate for their functions, and their sizes and cell types are different. In this review, we introduced recent studies of the microfluidic vascular models. The model structures are classified mainly as poly(dimethylsiloxane) and hydrogel microchannels and self-assembled networks. Basic phenomena and functions were realized in vascular models, including fluid shear stress, cell strain, interstitial flow, endothelial permeation, angiogenesis, and thrombosis. In some models, endothelial cells were co-cultured with smooth muscle cells, pericytes, and fibroblasts in an extracellular matrix. Examples of vascular models involving the brain, lung, liver, kidney, placenta, and cancer were also introduced.

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Citations

Nov 27, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Kae SatoAya Furuta
Nov 27, 2018·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Hitoshi Shiku
Mar 24, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Tadahiro YamashitaRyo Sudo
Oct 11, 2019·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Nobutoshi OtaYo Tanaka
Dec 27, 2019·Biomedical Microdevices·Mieradilijiang AbudupataerChunsheng Wang
Aug 18, 2020·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Ayaka NakaHiroharu Yui
Jan 2, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Gurneet S SanghaAlisa M Clyne
Jul 14, 2021·Journal of Biomechanical Engineering·Meghan E FallonMonica T Hinds
Nov 13, 2021·American Journal of Physiology. Heart and Circulatory Physiology·Feng GaoPingnian He

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