Recent Progress in the Discovery of Antifungal Agents Targeting the Cell Wall

Journal of Medicinal Chemistry
Wei LiuShengzheng Wang

Abstract

Due to the limit of available treatments and the emergence of drug resistance in the clinic, invasive fungal infections are an intractable problem with high morbidity and mortality. The cell wall, as a fungi-specific structure, is an appealing target for the discovery and development of novel and low-toxic antifungal agents. In an attempt to accelerate the discovery of novel cell wall targeted drugs, this Perspective will provide a comprehensive review of the progress made to date on the development of fungal cell wall inhibitors. Specifically, this review will focus on the targets, discovery process, chemical structures, antifungal activities, and structure-activity relationships. Although two types of cell wall antifungal agents are clinically available or in clinical trials, it is still a long way for the other cell wall targeted inhibitors to be translated into clinical applications. Future efforts should be focused on the identification of inhibitors against novel conserved cell wall targets.

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Citations

May 8, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·M Ángeles CurtoJuan C G Cortés
Jun 22, 2021·Journal of Enzyme Inhibition and Medicinal Chemistry·Xin WangJingyu Zhu
Oct 19, 2021·Journal of Medicinal Chemistry·Ji Won ChoiKi Duk Park

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