PMID: 16529537Mar 15, 2006Paper

Recent progress in the syntheses and biological evaluation of boronated porphyrins for boron neutron-capture therapy

Anti-cancer Agents in Medicinal Chemistry
M W RennerM G H Vicente

Abstract

Boronated porphyrins are an important class of tumor-localizing agents in two bimodal therapies for cancer currently under study experimentally and clinically; boron neutron-capture therapy (BNCT) and photodynamic therapy (PDT). The desirable properties for the boronated porphyrins are that they are easily synthesized, pure and well-characterized drugs, and that in vivo, they are stable, tumor-specific, with high tumor:blood and tumor:normal tissue boron concentration ratios, and cause minimal toxicity. A large number of new porphyrins and their syntheses are presented herein. The focus is primarily on porphyrins published within the past 5 years, but the implications and trends from porphyrins studied in vivo over the past 15 years are also reviewed. Many possess quite unusual, novel structures and others have appended cell-targeting moieties for greater tumor specificity. Besides the commonly used closo- and nido-o-carboranes other boron cages and modes of attachment are presented. These boron cages can selectively alter the lipophilic, hydrophilic and amphiphilic properties of the porphyrins as well as their boron content. New delivery modalities have also greatly improved the targeting potential of compounds previously deem...Continue Reading

Citations

Dec 1, 2007·Chemical Communications : Chem Comm·Werner TjarksRolf F Barth
Sep 18, 2010·Journal of Neuro-oncology·Shinji KawabataM Graça H Vicente
Jun 3, 2016·Neurologia Medico-chirurgica·Shin-Ichi MiyatakeKoji Ono
Aug 7, 2007·Chemistry : a European Journal·Erhong HaoM Graça H Vicente
Dec 1, 2006·Chemical Communications : Chem Comm·Erhong HaoM Graça H Vicente
Mar 15, 2013·International Journal of Radiation Biology·Henry M SmilowitzMichiko Miura
Jan 21, 2012·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Anastasija V EfremenkoAlexey V Feofanov
Jun 20, 2018·Cancer Communications·Rolf F BarthWeilian Yang
Nov 22, 2007·Photochemistry and Photobiology·Yongqing WeiQifeng Yang
Oct 7, 2006·Organic & Biomolecular Chemistry·Valentina A Ol'shevskayaAlexander A Shtil
Jan 22, 2011·Lasers in Surgery and Medicine·Ryo HiramatsuM Graça H Vicente
Apr 27, 2013·Future Medicinal Chemistry·Ahmed KhalilWerner Tjarks
Apr 27, 2013·Future Medicinal Chemistry·Zhu Yinghuai, Narayan S Hosmane
Apr 23, 2020·Future Medicinal Chemistry·Anastasija A IgnatovaAlexey V Feofanov
Jul 18, 2020·Journal of Neuro-oncology·Shin-Ichi MiyatakeKoji Ono
Feb 16, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Andrey A SemioshkinVladimir I Bregadze
Oct 8, 2014·Therapeutic Delivery·Diana SamarooNaphtali O'Connor
Jun 28, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Frédéric LerougeRosario Núñez
Oct 25, 2008·Bioconjugate Chemistry·Erhong HaoM Graça H Vicente

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.