Recent Progress in Therapeutic Strategies for Ischemic Stroke

Cell Transplantation
Toru Yamashita, Koji Abe

Abstract

Possible strategies for treating stroke include neuroprotection in the acute phase of cerebral ischemia and stem cell therapy in the chronic phase of cerebral ischemia. Previously, we have studied the temporal and spatial expression patterns of c-fos, hypoxia inducible factor-1α (HIF-1α), heat shock protein 70 (HSP70), and annexin V after 90 min of transient middle cerebral occlusion in rats and concluded that there is a time window for neuroprotection from 12 to 48 h after ischemia. In addition, we have estimated the neuroprotective effect of glial cell line-derived neurotrophic factor (GDNF) by injecting Sendai viral vector containing the GDNF gene into the postischemic brain. This Sendai virus-mediated gene transfer of GDNF showed a significant neuroprotective effect in the ischemic brain. Additionally, we have administered GDNF and hepatocyte growth factor (HGF) protein into the postischemic rat brain and estimated the infarct size and antiapoptotic and antiautophagic effects. GDNF and HGF significantly reduced infarct size, the number of microtubule-associated protein 1 light chain 3 (LC3)-positive cells, and the number of terminal deoxynucleotidyl transferase-mediated dUTP-biotin in situ nick-end labeling (TUNEL)-positive...Continue Reading

References

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Jun 15, 2010·Journal of the Neurological Sciences·Jackie TranStephen R Leeder
Nov 9, 2010·Cell Transplantation·Toru YamashitaKoji Abe

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Citations

Mar 24, 2016·International Journal of Molecular Sciences·Zhen JinLiang-Jun Yan
Jan 23, 2019·Cell Transplantation·Wenchao ZhangJiping Tang
Feb 26, 2019·Neural Regeneration Research·Ling-Yi LiaoQiang Gao
Sep 12, 2019·Anais Da Academia Brasileira De Ciências·Lei SunWei-Feng Wu
Oct 27, 2018·Molecular Medicine Reports·Pengcheng XingDonglian Wang
Jan 30, 2019·Frontiers in Neuroscience·Yulin SunGuozheng Ying
Oct 15, 2019·Frontiers in Cellular Neuroscience·Yang YangHua Feng
Apr 20, 2021·Frontiers in Cell and Developmental Biology·Guoyang ZhouLin Wang

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