Recent progress in tissue optical clearing

Laser & Photonics Reviews
Dan ZhuValery V Tuchin

Abstract

Tissue optical clearing technique provides a prospective solution for the application of advanced optical methods in life sciences. This paper gives a review of recent developments in tissue optical clearing techniques. The physical, molecular and physiological mechanisms of tissue optical clearing are overviewed and discussed. Various methods for enhancing penetration of optical-clearing agents into tissue, such as physical methods, chemical-penetration enhancers and combination of physical and chemical methods are introduced. Combining the tissue optical clearing technique with advanced microscopy image or labeling technique, applications for 3D microstructure of whole tissues such as brain and central nervous system with unprecedented resolution are demonstrated. Moreover, the difference in diffusion and/or clearing ability of selected agents in healthy versus pathological tissues can provide a highly sensitive indicator of the tissue health/pathology condition. Finally, recent advances in optical clearing of soft or hard tissue for in vivo imaging and phototherapy are introduced. [Formula: see text].

References

Apr 6, 1990·Science·W DenkW W Webb
May 1, 1970·Annals of the Rheumatic Diseases·W RedischC McEwen
Apr 1, 1999·Lasers in Surgery and Medicine·G VargasA J Welch
Aug 15, 2002·Journal of Biomedical Optics·Zachary S SacksGerard A Mourau
Dec 20, 2002·Nature·Jaime GrutzendlerWen-Biao Gan
Jul 26, 2003·Journal of Biomedical Optics·Haiying ChengHui Gong
Dec 17, 2003·The Journal of Investigative Dermatology·Alvin T YehBruce J Tromberg
Mar 9, 2004·Lasers in Surgery and Medicine·Misbah H KhanJ Stuart Nelson
Oct 7, 2004·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·M Rossi, A Carpi
Jan 25, 2005·Lasers in Surgery and Medicine·Bernard ChoiJ Stuart Nelson
Mar 19, 2005·Proceedings of the National Academy of Sciences of the United States of America·Pankaj KarandeSamir Mitragotri
Apr 13, 2005·Lasers in Surgery and Medicine·Roger J McNicholsMassoud Motamedi
Oct 1, 2005·Lasers in Surgery and Medicine·O F StumppJ Neev
Oct 11, 2005·Biophysical Journal·Sergey PlotnikovPaul J Campagnola
Mar 11, 2006·Journal of Biomedical Optics·Alvin T Yeh, Jason Hirshburg
Sep 13, 2006·Journal of Biomedical Optics·Jason HirshburgAlvin T Yeh
Sep 13, 2006·Journal of Biomedical Optics·Christopher G RylanderA J Welch
Sep 13, 2006·Journal of Biomedical Optics·O StumppA J Welch
Sep 13, 2006·Journal of Biomedical Optics·E Duco JansenJohn Virostko
Oct 18, 2006·Lasers in Surgery and Medicine·V V TuchinI V Yaroslavsky
Feb 22, 2007·Lasers in Surgery and Medicine·Jason HirshburgAlvin T Yeh
Mar 27, 2007·Cell·Hui-Hao LinAnn-Shyn Chiang
May 26, 2007·Investigative Ophthalmology & Visual Science·Mohamad G GhosnKirill V Larin
Mar 5, 2008·Journal of Biomedical Optics·Mohamad G GhosnKirill V Larin
Mar 29, 2008·The Journal of Investigative Dermatology. Symposium Proceedings·Wenyuan Zhu, Jie Gao
May 10, 2008·Journal of Biomedical Optics·Valery V TuchinAlvin T Yeh
May 10, 2008·Journal of Biomedical Optics·Jinhee YoonByungjo Jung
May 10, 2008·Journal of Biomedical Optics·Zongzhen MaoZhenzhen Han

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Citations

Sep 10, 2014·Diabetes, Obesity & Metabolism·S-C TangH-J Chien
Jul 10, 2014·The Journal of Investigative Dermatology·Philip L TongWolfgang Weninger
Jul 5, 2015·Microvascular Research·Ciara M McErleanSimon J Doran
Mar 12, 2015·Journal of Biophotonics·Daria K TuchinaValery V Tuchin
Jul 4, 2015·Cytometry. Part a : the Journal of the International Society for Analytical Cytology·Yuanzhen SuoChunmeng Shi
Jul 24, 2015·Biomedical Optics Express·Jason C BurtonIrina V Larina
Jan 11, 2014·Biomedical Optics Express·Yulian A MenyaevVladimir P Zharov
Aug 17, 2014·Tissue Engineering. Part C, Methods·Molly E Boutin, Diane Hoffman-Kim
Dec 17, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Ian H Guldner, Siyuan Zhang
Jul 30, 2014·Frontiers in Neuroanatomy·Michal StawarskiJakub Wlodarczyk
Dec 17, 2014·Lasers in Medical Science·Julia GallwasUwe Mortensen
Dec 9, 2014·Nature Methods·Guoying YangPaul A Heppenstall
Apr 26, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Saul Mujica AscencioMaxim E Darvin
Nov 12, 2015·BioTechniques·Pranita K KabadiKim Boekelheide
Dec 23, 2016·Journal of Biophotonics·Rui ShiDan Zhu
Jan 31, 2017·Journal of Biophotonics·Anton SdobnovValery Tuchin
Dec 2, 2017·Lab on a Chip·Tomas Silva SantistebanMatthias Meier

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Methods Mentioned

BETA
imaging techniques
imaging technique
light scattering
electron microscopy
transmission electron microscopy
fluorescence microscopy
irradiate
random light scattering
confocal microscopy
biopsies

Software Mentioned

FocusClear
IAD
TPEFM
Amira
3DISCO

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