Recent progress of sodium-glucose transporter 2 inhibitors as potential antidiabetic agents

Future Medicinal Chemistry
Yajing ZhangDayong Zhang

Abstract

SGLT2 inhibitors were promising and novel antidiabetic drugs which suppressed glucose reabsorption and increased urinary glucose exertion. This review paper are aimed to summarize the recent progress of SGLT2 inhibitors during the last 5 years. This paper first summarizes the information of SGLT2 inhibitors, including mechanism, evolution and then focuses on the recent efforts on structure-activity relationships and structural optimization of SGLT2 inhibitors. Finally, the corresponding clinical therapeutic efficacy and adverse drug reaction in patients with Type 2 diabetes are discussed in detail.

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Citations

Feb 6, 2020·Bioorganic & Medicinal Chemistry·Jayanta Dowarah, Ved Prakash Singh
Jan 14, 2020·Journal of Medicinal Chemistry·F Anthony RomeroRandall L Halcomb
Jul 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Khaled D KhalilMohamed Hagar

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BETA
amputations

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