Recent Progress on Manganese-Based Nanostructures as Responsive MRI Contrast Agents

Chemistry : a European Journal
Lorena García-HeviaJ Gallo

Abstract

Manganese-based nanostructured contrast agents (CAs) entered the field of medical diagnosis through magnetic resonance imaging (MRI) some years ago. Although some of these Mn-based CAs behave as classic T1 contrast enhancers in the same way as clinical Gd-based molecules do, a new type of Mn nanomaterials have been developed to improve MRI sensitivity and potentially gather new functional information from tissues by using traditional T1 contrast enhanced MRI. These nanomaterials have been designed to respond to biological environments, mainly to pH and redox potential variations. In many cases, the differences in signal generation in these responsive Mn-based nanostructures come from intrinsic changes in the magnetic properties of Mn cations depending on their oxidation state. In other cases, no changes in the nature of Mn take place, but rather the nanomaterial as a whole responds to the change in the environment through different mechanisms, including changes in integrity and hydration state. This review focusses on the chemistry and MR performance of these responsive Mn-based nanomaterials.

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Citations

Jul 10, 2019·Chemical Communications : Chem Comm·Juan PellicoJason J Davis
Nov 30, 2019·Chemical Communications : Chem Comm·Ehsan Nazarzadeh ZareVinod V T Padil
Oct 20, 2020·Contrast Media & Molecular Imaging·Alessio SmeraldoEnza Torino
Dec 29, 2020·Drug Delivery·Jiali LiZhiping Zhang
Mar 11, 2021·Biomaterials Science·Peng LiuWenhu Zhou

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