Recent progresses in small-molecule enzymatic fluorescent probes for cancer imaging

Chemical Society Reviews
Hong-Wen LiuWeihong Tan

Abstract

Abnormal enzymatic activities are directly related to the development of cancers. Identifying the location and expression levels of these enzymes in live cancer cells have considerable importance in early-stage cancer diagnoses and monitoring the efficacy of therapies. Small-molecule fluorescent probes have become a powerful tool for the detection and imaging of enzymatic activities in biological systems by virtue of their higher sensitivity, nondestructive fast analysis, and real-time detection abilities. Moreover, due to their structural tailorability, numerous small-molecule enzymatic fluorescent probes have been developed to meet various demands involving real-time tracking and visualizing different enzymes in live cancer cells or in vivo. In this review, we provide an overview of recent advances in small-molecule enzymatic fluorescent probes mainly during the past decade, including the design strategies and applications for various enzymes in live cancer cells. We also highlight the challenges and opportunities in this rapidly developing field of small-molecule fluorescent probes for interventional surgical imaging, as well as cancer diagnosis and therapy.

References

May 1, 1981·Journal of Medicinal Chemistry·P L CarlJ A Katzenellenbogen
Sep 26, 1995·Proceedings of the National Academy of Sciences of the United States of America·G P DimriO Pereira-Smith
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·M J ScanlanW J Rettig
Dec 9, 1994·Journal of Medicinal Chemistry·R J HodgkissM R Stratford
Feb 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·A Taylor
Jun 28, 1996·The Journal of Biological Chemistry·L A Verkruyse, S L Hofmann
Mar 5, 1996·Proceedings of the National Academy of Sciences of the United States of America·J MoskovitzN Brot
Sep 18, 1997·Journal of the National Cancer Institute·A F Chambers, L M Matrisian
Jun 1, 2001·Nature Medicine·C BremerR Weissleder
Aug 2, 2001·Proceedings of the National Academy of Sciences of the United States of America·T SandalovaG Schneider
May 4, 2002·Nature Cell Biology·Philip Cohen
Mar 14, 2003·Nature·Sam Hanash
May 30, 2003·Biochemical Society Transactions·M R RedinboP M Potter
Dec 31, 2003·Neurotoxicology·Antonietta NicotraOrnella Senatori
Mar 5, 2004·Cancer Research·Ching-Hsuan TungRalph Weissleder
May 5, 2004·Chemistry & Biology·Anna E Speers, Benjamin F Cravatt
May 14, 2004·Neoplasia : an International Journal for Oncology Research·Shanta M MesserliChing-Hsuan Tung
Jul 13, 2004·Cancer Treatment Reviews·S DansonM Ranson
Aug 3, 2004·Nature Biotechnology·Antonio MacchiaruloJanet M Thornton
Sep 11, 2004·Current Opinion in Biotechnology·Karl-Erich Jaeger, Thorsten Eggert
Nov 3, 2004·Nature Reviews. Molecular Cell Biology·Stefan J Riedl, Yigong Shi
Dec 17, 2004·Proceedings of the National Academy of Sciences of the United States of America·Tao JiangRoger Y Tsien
Feb 1, 2005·Biochimica Et Biophysica Acta·Herbert WeissbachNathan Brot
Mar 31, 2005·Journal of the American Chemical Society·Gong ChenDalibor Sames
Sep 28, 2005·International Journal of Cancer. Journal International Du Cancer·Chihiro KondoFumitaka Kikkawa
Jan 13, 2006·Nature Chemical Biology·Galia BlumMatthew Bogyo
Mar 7, 2006·Bioorganic & Medicinal Chemistry Letters·Nan-Hui HoChing-Hsuan Tung
Mar 16, 2006·Journal of the American Chemical Society·Kwangmeyung KimIck Chan Kwon
Mar 23, 2006·Nature Reviews. Neuroscience·Moussa B H YoudimKeith F Tipton
Mar 25, 2006·Nature Reviews. Cancer·Arne OstmanFrank D Böhmer
Sep 23, 2006·Nature Reviews. Cancer·Mona Mostafa Mohamed, Bonnie F Sloane
Sep 26, 2006·Trends in Pharmacological Sciences·Anne ThiryClaudiu T Supuran
Nov 4, 2006·Cell Death and Differentiation·S Kumar
Nov 30, 2006·Biological Chemistry·Mikiko MatsuiLinda L Walling
Dec 15, 2006·Journal of the American Chemical Society·Toru KomatsuTetsuo Nagano
Feb 22, 2007·The Journal of Biological Chemistry·Stefaan SansenEric F Johnson
Feb 23, 2007·Nature·Jennifer Y Lin, David E Fisher

❮ Previous
Next ❯

Citations

Jan 8, 2019·Chemistry : a European Journal·Kelsey M BoyleJacqueline K Barton
Jan 16, 2019·Chemistry : a European Journal·Hong-Bo ChengJuyoung Yoon
Apr 9, 2019·Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology·Tsutomu Ishi-IYoshinori Hagiwara
Jul 10, 2019·Chemical Communications : Chem Comm·Wei TuoThierry Le Gall
Sep 7, 2019·Mikrochimica Acta·Taiping QingBo Feng
Feb 6, 2020·Chemical Communications : Chem Comm·Rao WeiHai-Yu Hu
Feb 8, 2020·Chemical Communications : Chem Comm·Lanning ZhaoJianguo Fang
Feb 13, 2020·Chemical Communications : Chem Comm·Shohei UchinomiyaAkio Ojida
Apr 10, 2020·Dalton Transactions : an International Journal of Inorganic Chemistry·Wenzhu ZhangRun Zhang
Oct 13, 2019·Angewandte Chemie·Kevin J BruemmerChristopher J Chang
May 20, 2020·Chemistry, an Asian Journal·Zhimin Wang, Bengang Xing
Apr 4, 2020·Organic & Biomolecular Chemistry·Jong Min AnDokyoung Kim
Sep 10, 2020·Advanced Healthcare Materials·Yu DengGaolin Liang
Jul 11, 2020·Beilstein Journal of Organic Chemistry·Kazuyuki SatoMasaaki Omote
Jan 18, 2020·Micromachines·Yunlong BaiXueji Zhang
May 10, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Noriaki NakamuraAkio Ojida
Jul 31, 2019·Chemical Science·Peng GaoBo Tang
Jan 27, 2019·Chemical Communications : Chem Comm·Fei YanTony D James
Oct 19, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanqiang HaoShu Chen

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging
fluorescence imaging
imaging technique
xenografts
FRET
glycosylation
ELISA
lipidation
fluorescence microscopy
xenograft

Clinical Trials Mentioned

NCT01626066
NCT02438358
NCT02584244
NCT02391194

Software Mentioned

HyCoSuL
Lumicell

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.