Recent research milestones in the pathogenesis of human rickettsioses and opportunities ahead.

Future Microbiology
Hema P NarraSanjeev K Sahni

Abstract

Infections caused by pathogenic Rickettsia species continue to scourge human health across the globe. From the point of entry at the site of transmission by arthropod vectors, hematogenous dissemination of rickettsiae occurs to diverse host tissues leading to 'rickettsial vasculitis' as the salient feature of pathogenesis. This perspective article accentuates recent breakthrough developments in the context of host-pathogen-vector interactions during rickettsial infections. The subtopics include potential exploitation of circulating macrophages for spread, identification of new entry mechanisms and regulators of actin-based motility, appreciation of metabolites acquired from and effectors delivered into the host, importance of the toxin-antitoxin module in host-cell interactions, effects of the vector microbiome on rickettsial transmission, and niche-specific riboregulation and adaptation. Further research on these aspects will advance our understanding of the biology of rickettsiae as intracellular pathogens and should enable design and development of new approaches to counter rickettsioses in humans and other hosts.

References

Nov 1, 1979·Journal of Clinical Microbiology·J C GonderC E Pedersen
Oct 26, 1999·Infection and Immunity·S RadulovicA F Azad
Jan 30, 2004·Nature·Edith GouinPascale Cossart
Jul 9, 2004·Cellular Microbiology·Robert L JengMatthew D Welch
Aug 20, 2004·Journal of Bacteriology·Michael P McLeodGeorge M Weinstock
Feb 17, 2006·Annals of the New York Academy of Sciences·David H Walker, Xue-Jie Yu
Mar 31, 2009·Future Microbiology·Sanjeev K Sahni, Elena Rydkina
Jun 23, 2009·Annals of the New York Academy of Sciences·Sam R Telford
Mar 3, 2010·Infection and Immunity·Betsy KlebaTed Hackstadt
Mar 9, 2010·Trends in Parasitology·William L NicholsonSusan E Little
Oct 26, 2010·Nature Cell Biology·Cat M HaglundMatthew D Welch
Oct 29, 2010·Cold Spring Harbor Perspectives in Biology·Susan Gottesman, Gisela Storz
Sep 20, 2011·Molecular Cell·Gisela StorzKaren M Wassarman
Nov 3, 2011·PloS One·Gilles AudolyDidier Raoult
Apr 3, 2012·The Journal of Antimicrobial Chemotherapy·Elisabeth Botelho-NeversDidier Raoult
Jun 13, 2012·Nucleic Acids Research·Allison K Hansen, Nancy A Moran
Jul 10, 2012·Journal of Bacteriology·Simran J KaurAbdu F Azad
Jul 3, 2013·Proceedings of the National Academy of Sciences of the United States of America·Yadaiah MadasuRoberto Dominguez
Sep 26, 2013·Future Microbiology·Sanjeev K SahniDavid H Walker
Oct 5, 2013·Clinical Microbiology Reviews·Philippe ParolaDidier Raoult
Nov 13, 2013·Proceedings of the National Academy of Sciences of the United States of America·Bin GongXiaodong Cheng
Feb 15, 2014·The American Journal of Pathology·Natalie C Silmon de Monerri, Kami Kim
Jul 30, 2014·Microbiology·Heramb M Kulkarni, Medicharla V Jagannadham
Dec 17, 2014·Journal of Structural Biology·Marcia Folly-KlanValérie Campanacci
May 6, 2015·Trends in Parasitology·Sukanya Narasimhan, Erol Fikrig
May 9, 2015·Frontiers in Public Health·Marina E Eremeeva, Gregory A Dasch
Jul 2, 2015·Journal of Korean Medical Science·Sun-Myoung LeeJin-Soo Lee
Aug 21, 2015·PLoS Pathogens·Kristen E Rennoll-BankertAbdu F Azad

❮ Previous
Next ❯

Citations

Mar 31, 2021·Pathogens and Disease·Jon McGinn, Rebecca L Lamason

❮ Previous
Next ❯

Methods Mentioned

BETA
ubiquitination
proteomic profiling

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
David H Walker
© 2021 Meta ULC. All rights reserved