Recent Strategies Combining Biomaterials and Stem Cells for Bone, Liver and Skin Regeneration

Current Stem Cell Research & Therapy
Sabrina MorelliLoredana De Bartolo

Abstract

This review is focused on the combination of biomaterials with stem cells as a promising strategy for bone, liver and skin regeneration. At first, we describe stem cell-based constructs for bone tissue engineering with special attention to recent advanced approaches based on the use of biomaterial scaffolds with renewable stem cells that have been used for bone regeneration. We illustrate the strategies to improve liver regeneration by using liver stem cells and biomaterials and/or devices as therapeutic approaches. In particular, examples of biomaterials in combination with other technologies are presented since they allow the differentiation of stem cells in hepatocytes. After a description of the role and the benefit of MSCs in wound repair and in skin substitutes we highlight the suitability of biomaterials in guiding stem cell differentiation for skin regeneration and cutaneous repair in both chronic and acute wounds. Finally, an overview of the types of bioreactors that have been developed for the differentiation of stem cells and are currently in use, is also provided. The examples of engineered microenvironments reported in this review indicate that a detailed understanding of the various factors and mechanisms that con...Continue Reading

Citations

Oct 4, 2018·Current Stem Cell Research & Therapy·Mukta AgrawalShailendra Saraf
Dec 18, 2018·Journal of Biomaterials Science. Polymer Edition·Fangqing YinShijuan Zhan
Oct 7, 2020·Journal of Biomedical Materials Research. Part a·Yinping TianXiangning Liu
Sep 17, 2019·Colloids and Surfaces. B, Biointerfaces·Pritam DasLoredana De Bartolo
Sep 22, 2020·Bioactive Materials·Lu ChenXiaoming Sun

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