Recent strategies for inhibiting multidrug-resistant and β-lactamase producing bacteria: A review.

Colloids and Surfaces. B, Biointerfaces
Huma FatimaSunil Kumar Khare

Abstract

β-lactam antibiotics are one of the most commonly used drugs for treating bacterial infections, but their clinical effectiveness has been severely affected with bacteria developing resistance against their action. Production of β-lactamase enzymes by bacteria that can degrade β-lactams is the most common mechanism of acquiring such resistance, leading to the emergence of multiple-drug resistance in them. Therefore, the development of efficient approaches to combat infections caused by β-lactamase producing and multidrug-resistant bacteria is the need of the hour. The present review attempts to understand such recent strategies that are in line for development as potential alternatives to conventional antibiotics. We find that apart from efforts being made to develop new antibiotics, several other approaches are being explored, which can help tackle infections caused by resistant bacteria. This includes the development of plant-based drugs, antimicrobial peptides, nano-formulations, bacteriophage therapy, use of CRISPR-Cas9, RNA silencing and antibiotic conjugates with nanoparticles of antimicrobial peptides. The mechanism of action of these novel approaches and potential issues limiting their translation from laboratory to clin...Continue Reading

References

Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·P C Zamecnik, M L Stephenson
Aug 9, 2003·Journal of Clinical Microbiology·P GiakkoupiA C Vatopoulos
Apr 28, 2005·Antimicrobial Agents and Chemotherapy·Sang Hee Lee, Seok Hoon Jeong
Mar 30, 2006·Antimicrobial Agents and Chemotherapy·George A Jacoby
Dec 25, 2007·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·T NaasP Nordmann
Jan 13, 2009·Clinical Microbiology Reviews·George A Jacoby
Dec 10, 2009·Antimicrobial Agents and Chemotherapy·Karen Bush, George A Jacoby
Jan 13, 2010·Clinical Microbiology Reviews·Sarah M Drawz, Robert A Bonomo
Dec 3, 2013·Nature Nanotechnology·Che-Ming J HuLiangfang Zhang
Sep 23, 2014·Nature Biotechnology·Robert J CitorikTimothy K Lu
Nov 6, 2014·Acta Crystallographica. Section D, Biological Crystallography·Jeong Ho JeonSang Hee Lee
Dec 3, 2014·Drug Discovery Today·Keld Fosgerau, Torsten Hoffmann
Jan 7, 2015·Saudi Journal of Biological Sciences·Sibhghatulla ShaikhMohammad Amjad Kamal
Oct 28, 2015·Journal of Microbiology and Biotechnology·Jun-Seob KimDae-Hyuk Kweon
Jan 6, 2016·Antimicrobial Agents and Chemotherapy·Guozhi YuJens Rolff
Apr 14, 2016·Nature·Stineke van HouteEdze R Westra
Apr 22, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David van Duin, Robert A Bonomo
Nov 5, 2016·American Journal of Infection Control·Anaelís C CamposJorge J V Teixeira
Aug 6, 2016·ACS Nano·Kaiyuan ZhengJianping Xie
Aug 31, 2016·Nature Microbiology·April PawlukAlan R Davidson
Sep 15, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Ryan K ShieldsM Hong Nguyen
Sep 23, 2016·Frontiers in Microbiology·Apostolos LiakopoulosDaniela Ceccarelli
Jan 15, 2017·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yue ZhangLiangfang Zhang
Feb 9, 2017·Antimicrobial Agents and Chemotherapy·Yasufumi MatsumuraJohann D D Pitout
Feb 10, 2017·Avicenna Journal of Medicine·Trupti BajpaiG S Bhatambare
Feb 17, 2017·Nature Communications·Hyeran KimSang-Gyu Kim
Mar 1, 2017·International Journal of Nanomedicine·Linlin WangLongquan Shao
Mar 7, 2017·Frontiers in Neuroscience·Jianguo LiRoger W Beuerman
Mar 17, 2017·Journal of Peptide Science : an Official Publication of the European Peptide Society·Begum AlaybeyogluElif Ozkirimli
Mar 18, 2017·Drugs·Darren Wong, David van Duin
Aug 30, 2017·Oncology Reports·Dong-Mei WangFeng-Ping Shan
Dec 1, 2017·International Journal of Nanomedicine·Hassan A Hemeg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

CRISPR Ribonucleases Deactivation

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on mechanisms that underlie deactivation of CRISPR ribonucleases. Here is the latest research.

CRISPR Screens in Drug Resistance (ASM)

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

CRISPR & Staphylococcus

CRISPR-Cas system enables the editing of genes to create or correct mutations. Staphylococci are associated with life-threatening infections in hospitals, as well as the community. Here is the latest research on how CRISPR-Cas system can be used for treatment of Staphylococcal infections.

CRISPR Screens in Drug Resistance

CRISPR-Cas system enables the editing of genes to create or correct mutations. This feed focuses on the application of CRISPR-Cas system in high-throughput genome-wide screens to identify genes that may confer drug resistance.

CRISPRi Screens for Antibiotics

The CRISPR-Cas system is a gene editing technique that can be used for high-throughput genome-wide screens to identify modes of actions of novel antibiotics. Here is the latest research.

CRISPR (general)

Clustered regularly interspaced short palindromic repeats (CRISPR) are DNA sequences in the genome that are recognized and cleaved by CRISPR-associated proteins (Cas). CRISPR-Cas system enables the editing of genes to create or correct mutations. Discover the latest research on CRISPR here.

Related Papers

Expert Opinion on Therapeutic Patents
Karen Bush, Mark J Macielag
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Chaoyi XuJianhua Yin
Journal of Medicinal Chemistry
Concepción González-BelloEsther Colchón
Antibiotics
Daniela de Araújo Viana MarquesAna Lúcia Figueiredo Porto
© 2021 Meta ULC. All rights reserved