Recent translational research: stem cells as the roots of breast cancer

Breast Cancer Research : BCR
Chia-Cheng Chang

Abstract

Common phenotypes of cancer and stem cells suggest that breast cancers arise from stem cells. Breast epithelial cells with stem cell phenotypes have been shown to be more susceptible to immortalization and neoplastic transformation. Breast tumor stem cells with CD44+/CD24-/lowLineage- markers have been isolated. The role of these cells in tumor progression and clinical outcome is not clear. The relationship between breast stem cell and tumor stem cell may be elucidated by further studies of carcinogenesis of nonadherent mammosphere cells with stem cell features and by derivation of CD44+/CD24-/low cells from an adherent breast epithelial stem cell type.

References

Apr 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·S W LeeR Sager
Aug 1, 1990·Journal of the National Cancer Institute·I H RussoJ Russo
Jul 1, 1993·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R SagerG Sotiropoulou
Sep 1, 1996·Trends in Neurosciences·S WeissD van der Kooy
Aug 1, 1996·Seminars in Immunology·J E Dick
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Muhammad Al-HajjMichael F Clarke
May 21, 2003·Genes & Development·Gabriela DontuMax S Wicha
Dec 12, 2003·Proceedings of the National Academy of Sciences of the United States of America·Yi LiHarold E Varmus
Jan 15, 2005·Annals of the New York Academy of Sciences·James E TroskoMei-Hu Tai
Jul 1, 2005·Breast Cancer Research : BCR·Suling LiuMax S Wicha

❮ Previous
Next ❯

Citations

Feb 3, 2009·Carcinogenesis·Fabian L MuehlbergEckhard U Alt
Apr 4, 2009·Doklady Biological Sciences : Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections·A A LushnikovaA A Parokonnaya
Mar 31, 2012·Annals of Surgical Oncology·Xin YinJia Fan
Nov 12, 2009·Breast Cancer Research : BCR·Vaibhav P PaiNelson D Horseman
Jan 6, 2007·International Journal of Cancer. Journal International Du Cancer·Yaser AtlasiAhmad-Reza Bahrami
Sep 9, 2010·International Journal of Cancer. Journal International Du Cancer·Malek H AsadiYaser Atlasi
Apr 7, 2009·Journal of Surgical Oncology·Zhong ChenXue-Jing Xu
Apr 22, 2008·Biochemical and Biophysical Research Communications·Ji-Min SungHo-Chul Shin
Oct 14, 2006·Cancer·Axel SchulenburgPeter Valent
Oct 25, 2006·Experimental Biology and Medicine·Eun Hyun AhnJoseph J Schroeder
Aug 19, 2020·Life·Heba Al-SadikSherif M Karam
Oct 1, 2019·Dose-response : a Publication of International Hormesis Society·James E Trosko
Sep 10, 2019·Stem Cells and Development·Te-Chuan ChenChia-Cheng Chang
Jun 20, 2007·European Journal of Cell Biology·Stephan TiedeRalf Paus

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Cancer: Chemo-Resistance

Some cancers are difficult to treat and aggressive including the "triple-negative" breast cancer. This type of cancer is chemoresistant even before chemotherapy begins. Here are the latest discoveries chemo-resistance in breast cancer.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.