Recent trends in preclinical drug-drug interaction studies of flavonoids--Review of case studies, issues and perspectives

Phytotherapy Research : PTR
N R Srinivas

Abstract

Because of health benefits that are manifested across various disease areas, the consumption of herbal products and/or health supplements containing different kinds of flavonoids has been on the rise. While the drug-drug interaction potential between flavonoids and co-ingested drugs still remain an issue, opportunities exist for the combination of flavonoids with suitable anti-cancer drugs to enhance the bioavailability of anti-cancer drugs and thereby reduce the dose size of the anti-cancer drugs and improve its therapeutic index. In recent years, scores of flavonoids have undergone preclinical investigation with variety of drugs encompassing therapeutic areas such as oncology (etoposide, doxorubicin, paclitaxel, tamoxifen etc.), immunosuppression (cyclosporine) and hypertension (losartan, felodipine, nitrendipine etc.). The review provides examples of the recent trends in the preclinical investigation of 14 flavonoids (morin, quercetin, silibinin, kaempferol etc.) with various co-administered drugs. The relevance of combination of flavonoids with anti-cancer drugs and a framework to help design the in vitro and in vivo preclinical studies to gain better mechanistic insights are discussed. Also, concise discussions on the vari...Continue Reading

References

Jun 1, 1994·Free Radical Biology & Medicine·Y HanasakiS Fukui
Sep 28, 1999·Trends in Plant Science·R A Dixon, C L Steele
Sep 22, 2001·The American Journal of Clinical Nutrition·R J NijveldtP A van Leeuwen
Feb 23, 2002·Planta medica·Hung-Yi ChenPei-Dawn Lee Chao
Apr 17, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gary K SchwartzDavid Kelsen
Sep 28, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Antoinette R TanAdrian M Senderowicz
Nov 27, 2002·Cancer Chemotherapy and Pharmacology·James P ThomasGeorge Wilding
Feb 27, 2003·The Journal of Pharmacology and Experimental Therapeutics·Jun ChenMing Hu
Nov 25, 2003·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Yong LiuMing Hu
Apr 23, 2004·Molecular Pharmacology·Shuzhong ZhangMarilyn E Morris
Apr 19, 2005·Drug Metabolism and Disposition : the Biological Fate of Chemicals·Brigitte A GrafChristine A Edwards
Jun 11, 2005·Pharmaceutical Research·Xiao ChenMoses S S Chow
Sep 2, 2005·The Journal of Pharmacology and Experimental Therapeutics·Cornelia M SmithEdward L Lecluyse
Jun 10, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·C Y YangS L Hsiu
Sep 17, 2008·European Journal of Clinical Pharmacology·Anita N StumpfArmin Gerbitz
Sep 26, 2008·Inflammopharmacology·C HuoT H Chan
Feb 20, 2009·Biopharmaceutics & Drug Disposition·Joong-Hwa ChungJun-Shik Choi
May 20, 2009·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Richard D CarvajalEileen M O'Reilly
Jun 6, 2009·Journal of Pharmaceutical Sciences·Shuzhong ZhangMarilyn E Morris
Dec 29, 2009·European Journal of Pharmacology·Gangjun DuWei Liang
Mar 17, 2010·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·N R Srinivas
Jun 18, 2011·Journal of Clinical Pharmacology·Kai-Ming DuanLi-Jun Yang
Oct 22, 2011·International Journal of Molecular Sciences·Derliz Mereles, Werner Hunstein
Mar 1, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jason J LukeGary K Schwartz
May 16, 2012·Anti-cancer Agents in Medicinal Chemistry·Zhen YangMing Hu
Nov 20, 2012·European Journal of Drug Metabolism and Pharmacokinetics·Daniela Cristina VitaleSalvatore Salomone
Nov 29, 2012·Journal of Pharmaceutical Sciences·Pius FasinuViness Pillay
Apr 18, 2013·Journal of Agricultural and Food Chemistry·Pei-Wen HsuYu-Chi Hou
May 25, 2013·Current Pharmaceutical Design·Salvatore Chirumbolo
Jul 5, 2013·Phytotherapy Research : PTR·Barbara RomanoFrancesca Borrelli

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Citations

Mar 5, 2016·Journal of Enzyme Inhibition and Medicinal Chemistry·Jun YuWei Wei
Jun 17, 2016·Phytotherapy Research : PTR·Masoumeh Akhlaghi
Nov 9, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ji-Ye KeeSeung-Heon Hong
Nov 12, 2017·Molecular Nutrition & Food Research·Susanne AndresAlfonso Lampen
May 21, 2020·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·Ashish DograUtpal Nandi
Apr 14, 2021·Critical Reviews in Food Science and Nutrition·Abid NaeemZheng Qin
Jul 23, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Shanoo SuroowanMohamad Fawzi Mahomoodally
Aug 17, 2021·Annals of Medicine·Abby Keller, Taylor C Wallace

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