Recent trends in ZikV research: A step away from cure

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Aftab AlamRomana Ishrat

Abstract

Zika virus (ZikV) is a member of the Flaviviridae virus family, genus Flavivirus has emerged as a potential threat to human health worldwide. Consequences of vertical infections includes microcephaly with brain and eye anomalies, and adult infections includes Guillain-Barrésyndrome (GBS), brain ischemia, myelitis and meningoencephalitis. To develop a better treatment, many efforts are being made, like drug-repurposing concept for FDA-approved drugs for antiviral activity are screened against ZikV infection and emerging as a promising alternative to expedite drug development and various vaccines like DNA, ZPIV, LAIV, mRNA and AGS-v vaccines have been designed and in under clinical trial phases. Moreover, few pharmacological agents like Mycophenolicacid, Niclosamide, PHA-690509, Emricasan and Bortezomib are most potent anti-ZikV candidates and highly effective single or combining treatment with these drugs. This article reviews the ZikV illness, transmission patterns, pathophysiology of disease, global efforts, challenges and the prospects for the development of vaccines and antiviral agents.

Citations

Nov 14, 2017·Journal of Basic Microbiology·Farakh JavedSobia Manzoor
Oct 26, 2018·PLoS Neglected Tropical Diseases·Yu-Hsuan WuKung-Chia Young
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Jul 1, 2020·Turkish Journal of Biology = Türk Biyoloji Dergisi·Aftab AlamRomana Ishrat
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