Recent update on antibacterial and antifungal activity of quinoline scaffolds.

Archiv der Pharmazie
Atukuri Dorababu

Abstract

Although most of the heterocycles have been reported to possess a significant pharmacological activity, only a few of them, namely quinoline derivatives, have exhibited the finest biological activities. Despite the few medicinal properties of the plain quinoline molecule, its derivatives exhibit diverse pharmacological properties such as anticancer, anti-inflammatory, antibacterial, antiviral, antifungal, antiprotozoal activities, and so on. The potential antimicrobial properties of the quinoline derivatives are evident from the decades of research on these derivatives. Owing to limitations like drug resistance, high cost, severe side effects, and less bioavailability of previously synthesized antimicrobial agents, these drugs have become obsolete in recent years. Hence, the design of more efficient antimicrobial drugs must be given topmost priority. A breakthrough in drug discovery is a must to prevent malevolent microbial diseases. Addressing all these issues, researchers have been continuously contributing to antimicrobial drug discovery. Herein, a short description of the pharmacology of antimicrobial agents such as antibacterials and antifungals synthesized recently is provided. The versatile derivatization of the quinolin...Continue Reading

References

Feb 3, 2005·Nature Reviews. Drug Discovery·Curtis T KeithBrent R Stockwell
Mar 24, 2006·Chemistry : a European Journal·Li ShenRen-Xiang Tan
Aug 2, 2007·Accounts of Chemical Research·Bernard Meunier
Apr 1, 2014·Bioorganic & Medicinal Chemistry·Iwao OjimaJacob G Vineberg
Oct 21, 2015·BioMed Research International·Vladimir B SulimovFazoil I Ataullakhanov
May 18, 2016·Bioorganic & Medicinal Chemistry·Krupanandan HaranahalliIwao Ojima
Nov 26, 2016·European Journal of Medicinal Chemistry·Mitali MishraSushil Kumar Kashaw
Nov 9, 2017·European Journal of Medicinal Chemistry·Mohamed F El ShehryYousry A Ammar
Nov 12, 2017·European Journal of Medicinal Chemistry·Nulgumnalli Manjunathaiah RaghavendraS V U M Prasad
Nov 28, 2017·Journal of Photochemistry and Photobiology. B, Biology·Muthu ThangarajRamesh Muthusamy
Jan 25, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Anna EmpelAndrzej Zięba
Feb 13, 2018·Indian Journal of Microbiology·Jagdish R BadgujarJyotsna S Meshram
May 4, 2018·Journal of Enzyme Inhibition and Medicinal Chemistry·Ning SunKwok-Yin Wong
May 12, 2018·Bioorganic & Medicinal Chemistry·Shizhen ZhaoMaosheng Cheng
Jun 3, 2018·Bioorganic & Medicinal Chemistry·Peng TengJianfeng Cai
Jul 24, 2018·Journal of Medicinal Chemistry·Ewgenij ProschakDaniel Merk
Nov 19, 2018·Bioorganic & Medicinal Chemistry Letters·T G ShruthiSangeetha Subramanian
Jan 8, 2019·ACS Medicinal Chemistry Letters·Joshua MeyersMatthew D Cheeseman
Jan 19, 2019·Bioorganic & Medicinal Chemistry Letters·Pedro VillaShankar Thangamani
Jan 22, 2019·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Bruna PippiAlexandre Meneghello Fuentefria
Feb 6, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hai-Gen FuDan-Qing Song
Feb 23, 2019·Bioorganic & Medicinal Chemistry·Senyuan CaiNing Sun
Mar 1, 2019·Materials Science & Engineering. C, Materials for Biological Applications·Camila Dos Santos ChagasIzilda A Bagatin
Jul 7, 2019·European Journal of Medicinal Chemistry·Joanna FedorowiczAdyary Fallarero
Jul 28, 2019·Materials Science & Engineering. C, Materials for Biological Applications·M I Abou-DobaraA M Eldesoky
Dec 31, 2019·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Daiane Flores Dalla LanaGustavo Pozza Silveira

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Related Papers

Il Farmaco; edizione scientifica
F GIALDI, R PONCI
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Y Hamada, H SUGIHARA
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Y HamadaT ISOBE
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Y HamadaS Tomomatu
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Y Hamada, H SUGIHARA
© 2021 Meta ULC. All rights reserved