Recent updates in utilizing prodrugs in drug delivery (2013-2015)

Expert Opinion on Drug Delivery
Wajd Amly, Rafik Karaman

Abstract

Utilizing the prodrug approach as a method to overcome various pharmaceutical and pharmacokinetic barriers to drug delivery is significantly accelerating and achieving successes. In contrast to the older traditional prodrugs which suffer from decreased bioavailability and a high profile of side effects, due to activation at undesired sites, the targeted prodrug approach utilizes delivery systems to improve delivery for a wide range of therapeutics including anti-cancer, anti-bacterial and anti-inflammatory drugs. Recent updates in utilization of prodrugs in drug delivery between 2013 and 2015 are discussed. Targeted prodrugs against cancer, solid tumors, microbial infections, inflammation and other diseases using advanced delivery systems such as theranostic approaches, siRNA, DOX immunoconjugate, C 60-ser carrier vector, biotinylated prodrug, human serum albumin (HSA) carrier and others are presented. Recent research efforts have been directed at developing targeted prodrugs to replace the classical prodrugs. The use of this approach has accelerated following the emergence of encouraging results from several studies on targeted prodrugs that have highlighted their higher efficiency and improved safety profiles. Targeted prodru...Continue Reading

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Citations

Jun 9, 2016·Expert Opinion on Biological Therapy·Anna HagenhoffPeter J Nelson
Oct 17, 2017·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Hanadi SinokrotRafik Karaman
Nov 30, 2019·Expert Opinion on Drug Discovery·Suresh MaddilaSreekantha B Jonnalagadda
Apr 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Buthaina JubehRafik Karaman
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Valeria I RaskolupovaVladimir N Silnikov

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