Recently identified drug resistance biomarkers in ovarian cancer

Expert Review of Molecular Diagnostics
Ben Davidson

Abstract

Ovarian cancer, consisting mainly of ovarian carcinoma, is the most lethal gynecologic malignancy. Improvements in outcome for patients with advanced-stage disease are limited by intrinsic and acquired chemoresistance and by tumor heterogeneity at different anatomic sites and along disease progression. Molecules and cellular pathways mediating chemoresistance appear to be different for the different histological types of ovarian carcinoma, with most recent research focusing on serous and clear cell carcinoma. This review discusses recent data implicating various biomarkers in chemoresistance in this cancer, with focus on studies in which clinical specimens have been central.

References

Nov 30, 2006·Proceedings of the National Academy of Sciences of the United States of America·Kentaro NakayamaIe-Ming Shih
Jul 8, 2008·Human Pathology·C Blake GilksUNKNOWN Cheryl Brown Ovarian Cancer Outcomes Unit of the British Columbia Cancer Agency
Jan 27, 2009·International Journal of Cancer. Journal International Du Cancer·Alain G ZeimetChristian Marth
Jul 31, 2010·The American Journal of Pathology·Joon Tae ParkTian-Li Wang
Jan 18, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Ie-Ming ShihTian-Li Wang
Feb 18, 2011·International Journal of Cancer. Journal International Du Cancer·Osamu MaedaFumitaka Kikkawa
Feb 23, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Gong YangJinsong Liu
Mar 18, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·David S P TanJorge S Reis-Filho
May 17, 2011·Cancer Research·Euan A StronachHani Gabra
Jun 29, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Barbara NorquistElizabeth M Swisher
Jun 30, 2011·Virchows Archiv : an International Journal of Pathology·Hans BösmüllerFalko Fend
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 19, 2011·Molecular Pharmaceutics·Jean-Pierre GilletMichael M Gottesman
Aug 19, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Douglas C MarchionJohnathan M Lancaster
Nov 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Jean-Pierre GilletMichael M Gottesman
Nov 22, 2011·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Atsuko KatagiriKohji Miyazaki
Feb 11, 2012·Virchows Archiv : an International Journal of Pathology·Jaime Prat
Apr 12, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Pierre GilletMichael M Gottesman
May 12, 2012·Cancer Discovery·Nicolai J BirkbakAndrea L Richardson
May 23, 2012·Clinical & Experimental Metastasis·Erhong MengRodney P Rocconi
Jun 16, 2012·Virchows Archiv : an International Journal of Pathology·Emma WilliamsSuha Deen
Jun 20, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Kathryn AlsopGillian Mitchell
Aug 1, 2012·The Cancer Journal·Scott M WeissmanAnna C Newlin
Aug 23, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zhigang C WangUrsula A Matulonis
Nov 21, 2012·The Journal of Pathology·Louise J BarberAlan Ashworth
Nov 22, 2012·Gynecologic Oncology·Joyce N BarlinDouglas A Levine
Apr 5, 2013·PloS One·Souriya VangAlexander S Brodsky
May 24, 2013·Proceedings of the National Academy of Sciences of the United States of America·Andrea VecchioneCarlo M Croce
Jul 11, 2013·Nature Communications·Silvia DomckeNikolaus Schultz
Sep 26, 2013·Journal of the National Cancer Institute·Yu KangAnil K Sood
Sep 28, 2013·Critical Reviews in Oncology/hematology·Pierre-Emmanuel ColomboIsabelle Ray-Coquard

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Citations

Nov 9, 2016·Human Pathology·Esther Channah BronerBen Davidson
Dec 23, 2016·Journal of Biophotonics·Hamid MoradiSangeeta Murugkar
Jan 6, 2018·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Juliana A JosahkianJeremy A Squire
May 11, 2019·Expert Review of Molecular Diagnostics·Ben Davidson
Feb 8, 2020·Journal of Cellular Biochemistry·Caihua DongXia Liu
Jul 23, 2018·Virchows Archiv : an International Journal of Pathology·Hadil OnallahBen Davidson
Nov 24, 2018·Virchows Archiv : an International Journal of Pathology·Marta BrunettiBen Davidson
May 31, 2020·Virchows Archiv : an International Journal of Pathology·Ben DavidsonHiep Phuc Dong
Mar 14, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Brian Z RingUNKNOWN Australian Ovarian Cancer Study
Nov 19, 2018·Gynecologic Oncology·Karine Flem KarlsenBen Davidson
Mar 25, 2019·Gynecologic Oncology·Miriam Sherman-SamisBen Davidson

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