Recently integrated Alu elements and human genomic diversity

Molecular Biology and Evolution
Abdel-Halim SalemMark A Batzer

Abstract

A comprehensive analysis of two Alu Y lineage subfamilies was undertaken to assess Alu-associated genomic diversity and identify new Alu insertion polymorphisms for the study of human population genetics. Recently integrated Alu elements (283) from the Yg6 and Yi6 subfamilies were analyzed by polymerase chain reaction (PCR), and 25 of the loci analyzed were polymorphic for insertion presence/absence within the genomes of a diverse array of human populations. These newly identified Alu insertion polymorphisms will be useful tools for the study of human genomic diversity. Our screening of the Alu insertion loci also resulted in the recovery of several "young" Alu elements that resided at orthologous positions in nonhuman primate genomes. Sequence analysis demonstrated these "young" Alu insertions were the products of gene conversion events of older, preexisting Alu elements or independent parallel forward insertions of older Alu elements in the same short genomic region. The level of gene conversion between Alu elements suggests that it may have an influence on the single nucleotide polymorphism within Alu elements in the genome. We have also identified two genomic deletions associated with the retroposition and insertion of Alu ...Continue Reading

Citations

Jun 9, 2005·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·J L PrietoA M Chèvre
Jun 7, 2005·Molecular Phylogenetics and Evolution·Jinchuan XingMark A Batzer
Jun 10, 2005·Molecular Biology and Evolution·Andrew J GentlesJerzy Jurka
May 27, 2011·Molecular Biology and Evolution·Sergio Lukic, Kevin Chen
Dec 7, 2010·Genome Research·Fereydoun HormozdiariEvan E Eichler
Apr 3, 2004·Genome Research·Kateryna D MakovaFrancesca Chiaromonte
May 4, 2005·Genome Research·Kyudong HanMark A Batzer
Aug 19, 2005·Molecular and Cellular Biology·Nicolas GilbertJohn V Moran
Nov 17, 2004·Cytogenetic and Genome Research·J SchmitzH Zischler
Nov 17, 2004·Cytogenetic and Genome Research·M El-Sawy, P Deininger
Nov 17, 2004·Cytogenetic and Genome Research·A-H SalemM A Batzer
Aug 12, 2005·Cytogenetic and Genome Research·P MedstrandD L Mager
Aug 12, 2005·Cytogenetic and Genome Research·R K GarberM A Batzer
Feb 24, 2005·BMC Evolutionary Biology·Abdel-Halim SalemMark A Batzer
Oct 8, 2005·BMC Evolutionary Biology·David A Ray, Mark A Batzer
Jul 3, 2007·BMC Evolutionary Biology·Pamela Styles, John F Y Brookfield
May 16, 2009·BMC Evolutionary Biology·Pamela Styles, John F Y Brookfield
Dec 1, 2009·BMC Genomics·Tong J GuJames Q Yin
Feb 28, 2006·Genes & Genetic Systems·Eun-Sil ParkHeui-Soo Kim
Oct 5, 2005·PLoS Computational Biology·Dale J HedgesMark A Batzer
Jun 12, 2013·PloS One·Ana Teixeira-SilvaLuísa Azevedo
Oct 30, 2004·Genetics·E Andrew BennettScott E Devine
Dec 8, 2011·Human Biology·Loth CherniAmel Benammar-Elgaaied
Oct 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Abdel-Halim SalemMark A Batzer
Aug 8, 2013·Nucleic Acids Research·Matei DavidMichael Brudno
Aug 2, 2011·Annual Review of Genomics and Human Genetics·Christine R BeckJohn V Moran
Nov 26, 2003·Current Opinion in Genetics & Development·Prescott L DeiningerHaig H Kazazian
Nov 19, 2015·Mobile DNA·Lavanya RishishwarI King Jordan
Apr 20, 2007·Gene·Wanjun GuDavid D Pollock
Mar 3, 2007·Trends in Genetics : TIG·Ryan E MillsScott E Devine
Mar 2, 2005·Molecular Phylogenetics and Evolution·David A RayMark A Batzer
Jan 29, 2005·Genomics·Huei Jin HoMark A Batzer
May 17, 2006·Trends in Ecology & Evolution·Andrew M ShedlockNorihiro Okada
Nov 10, 2004·Journal of Molecular Biology·Jinchuan XingMark A Batzer
Sep 15, 2004·Trends in Genetics : TIG·Richard CordauxMark A Batzer
Nov 9, 2004·Current Opinion in Genetics & Development·Alexander E Vinogradov
Jul 10, 2004·Insect Biochemistry and Molecular Biology·Zhijian Tu, Craig Coates
Oct 24, 2006·Gene·Scott W HerkeMark A Batzer
May 17, 2005·Insect Biochemistry and Molecular Biology·Alessandra della TorreVincenzo Petrarca
Apr 22, 2005·Journal of Molecular Biology·Pauline A CallinanMark A Batzer

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of Molecular Biology
A M Roy-EngelMark A Batzer
Journal of Molecular Evolution
Jinchuan XingMark A Batzer
Journal of Molecular Evolution
Karla JohanningP L Deininger
Cytogenetic and Genome Research
Randall K GarberMark A Batzer
© 2022 Meta ULC. All rights reserved