PMID: 7543073May 1, 1995Paper

Receptive systems for drugs in salivary gland cells

Nihon yakurigaku zasshi. Folia pharmacologica Japonica
M Kawaguchi, H Yamagishi

Abstract

Investigators have demonstrated many types of receptors or acceptors for endogenous substances in salivary glands. These suggest that salivary glands contain receptive systems for many drugs. These receptors can be classified into three types based on the property of saliva secretion: (1) receptors involved in fluid secretion, (2) receptors involved in exocytosis for the protein secretion, (3) receptors involved in both types of secretion. The receptors involved in fluid secretion include the group of alpha 1B, M3, NK-1 receptors coupled with IP3; the group of beta 2 and VIP receptors coupled with cAMP; and the group of P2Z and P2U receptors coupled with the ATP-gated calcium channel. Whereas alpha 1A, beta 1, VIP, M3, insulin and H2 receptors mediate exocytosis via the cAMP-proteinkinase A pathway. Moreover, the another pathway of diacylglycerol-proteinkinase C has also been demonstrated to be involved in the exocytosis occurring via NK-1 and M3 receptors. Thus, salivary gland cells have many kinds of drug-receptor system. These receptors are all positive to fluid and/or protein exocytosis. Recently our study on the inhibitory regulation of saliva secretion have suggested the existence of GABA and the GABA-synthetic/metabolic ...Continue Reading

Citations

Dec 20, 2007·The American Journal of the Medical Sciences·Robert I HenkinA Papathanassiu
Feb 5, 2011·European Journal of Pharmacology·Kazunori OuchiMitsuru Kawaguchi
Mar 11, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Patrícia Del Vigna de AlmeidaLuciana Reis Azevedo
Jan 19, 2008·Periodontology 2000·Robin A Seymour, Meenakshi Rudralingham
Jul 31, 2004·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·C Scully, J-V Bagan
Jan 1, 2006·Toxicology Mechanisms and Methods·Abdollah Osman AhmedMohammad Abdollahi
Sep 17, 2003·Oral Diseases·C Scully
Jun 7, 2006·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Masahito WatanabeYasuko Ishikawa
Aug 5, 2020·Physiology International·O M EinhornA Tompa

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