Receptor accessory folding helper enzymes: the functional role of peptidyl prolyl cis/trans isomerases

FEBS Letters
C Schiene-Fischer, C Yu

Abstract

Receptor accessory peptidyl prolyl cis/trans isomerases (PPIases) of the FKBP and cyclophilin types form receptor heterocomplexes with different stabilities. PPIases have been found to associate with other receptor heterocomplex constituents via either proline-directed active sites or additional domains of the enzymes. The single-domain PPIases FKBP12 and FKBP12.6 are shown to interact with receptor protein kinases and calcium channels at their active sites. In contrast, heterooligomeric nuclear receptors contain multi-domain PPIases like FKBP51, FKBP52 or cyclophilin 40 that directly interact with the chaperone hsp90 via the tetratricopeptide repeat modules of the folding helper enzymes. PPIases play a critical role in the functional arrangement of components within receptor heterocomplexes.

References

Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D A PeattieM Benasutti
Jul 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·I CallebautJ P Mornon
Jan 1, 1994·The Journal of Steroid Biochemistry and Molecular Biology·J M RenoirE E Baulieu
Nov 8, 1994·Proceedings of the National Academy of Sciences of the United States of America·C RadanyiE E Baulieu
Jul 19, 1996·The Journal of Biological Chemistry·A Kralli, K R Yamamoto
Jul 1, 1996·Physiological Reviews·A R Marks
Sep 20, 1996·The Journal of Biological Chemistry·M J CharngM D Schneider
Dec 6, 1996·Science·S BoseJ Buchner
Apr 25, 1997·The Journal of Biological Chemistry·L A Carver, C A Bradfield
Jul 1, 1997·The EMBO Journal·Y G ChenJ Massague
Feb 7, 1998·Proceedings of the National Academy of Sciences of the United States of America·Y MiyataE E Baulieu
Mar 21, 1998·Insect Biochemistry and Molecular Biology·Q SongL I Gilbert
May 23, 1998·The Journal of Biological Chemistry·M Lopez-IlasacaR Wetzker
Oct 23, 1998·Genomics·X MengM T Keating
Apr 25, 2000·The Journal of Biological Chemistry·D YaoE B Leof

❮ Previous
Next ❯

Citations

Mar 20, 2008·JAMA : the Journal of the American Medical Association·Elisabeth B BinderKerry J Ressler
Jan 31, 2012·Biomolecular NMR Assignments·Miriam LinnertChristian Lücke
Aug 9, 2003·International Journal for Parasitology·Clare S GaviganAngus Bell
May 7, 2003·The Journal of Steroid Biochemistry and Molecular Biology·Sanjay ChauhanRoger L Miesfeld
Nov 23, 2011·Biochemistry·Sebastian MatheaCordelia Schiene-Fischer
Jan 4, 2003·Nature Cell Biology·Colin AdrainSeamus J Martin
Jan 3, 2003·Nature Cell Biology·Michiko Shirane, Keiichi I Nakayama
Nov 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sonja HorstmannElisabeth B Binder
Nov 2, 2002·The Plant Journal : for Cell and Molecular Biology·Thilo KamphausenJens-U Rahfeld
May 14, 2010·The Journal of Biological Chemistry·Gin-Ah SongHyun-Mo Ryoo
Aug 9, 2003·Nucleic Acids Research·Dierk IngelfingerTilmann Achsel
Oct 14, 2004·European Journal of Biochemistry·Lena M HenrikssonSherry L Mowbray
Oct 26, 2002·Journal of Bacteriology·Nayoung KimGeorge Sachs
Jul 14, 2010·European Journal of Medical Research·A HolowniaJ J Braszko
Feb 7, 2002·Proceedings of the National Academy of Sciences of the United States of America·Kristine N BrazinAmy H Andreotti
Nov 8, 2003·Proceedings of the National Academy of Sciences of the United States of America·Sigrid DuboisJürgen R Müller
Jun 3, 2011·Harvard Review of Psychiatry·Sonja Horstmann, Elisabeth B Binder
Dec 17, 2009·Neuroscience and Biobehavioral Reviews·Nicolas RohlederOliver T Wolf
Jul 1, 2009·Pharmacology & Therapeutics·Sonja Horstmann, Elisabeth B Binder
Mar 25, 2011·The Journal of Investigative Dermatology·So Young KimSoo Young Choi
Aug 8, 2015·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Anthony S ZannasElisabeth B Binder
Sep 1, 2005·Yeast·Trevor J Pemberton, John E Kay
Sep 15, 2009·Depression and Anxiety·Charles F GillespieKerry J Ressler
May 30, 2008·Chembiochem : a European Journal of Chemical Biology·Nicole WehofskyFrank Bordusa
Mar 19, 2014·Frontiers in Neuroendocrinology·Leonidas Panagiotakopoulos, Gretchen N Neigh
Nov 14, 2013·Genes, Brain, and Behavior·A S Zannas, E B Binder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.