Receptor autoimmunity in endocrine disorders

The New England Journal of Medicine
T J Wilkin


The discovery in 1956 of the long-acting thyroid stimulator of Graves' disease, now known as thyroid-stimulating antibodies, was seminal. A new mechanism for disease was revealed that appears applicable to virtually all endocrine systems, involving the growth as well as the function of endocrine cells. An endocrine gland may fail through at least three autoimmune mechanisms: destruction, atrophy, and inhibition of function. Destruction is probably irreversible but is not usually distinguishable clinically from receptor blockade causing atrophy or from metabolic unresponsiveness. The contribution made by receptor autoimmunity to endocrine diseases other than thyroid disease is at present unclear, but with immunologic manipulation it is potentially reversible, improving the replicative capacity of the gland, its metabolic responsiveness, or both.


Dec 9, 1978·Lancet·H JüppnerR D Hesch
Feb 1, 1976·The Journal of Clinical Endocrinology and Metabolism·J OrgiazziD H Solomon
Dec 29, 1989·Biochemical and Biophysical Research Communications·Y NagayamaB Rapoport
Sep 2, 1989·Lancet·S C BoyagesH A Drexhage
Dec 29, 1989·Biochemical and Biophysical Research Communications·F LibertG Vassart
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·R D van der GaagD Doniach
Jan 1, 1985·Endocrine Reviews·K D Burman, J R Baker
Oct 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J T PosillicoE M Brown
Feb 1, 1988·Journal of Endocrinological Investigation·B E WenzelP C Scriba
Aug 24, 1974·Lancet·B R Smith, R Hall
Aug 1, 1974·Annals of Internal Medicine·Y HirataA Noguchi
Jul 1, 1973·Clinical Endocrinology·I Doniach, A G Morgan
Jun 1, 1982·The Journal of Clinical Endocrinology and Metabolism·V ChiauzziE H Charreau
Dec 2, 1982·The New England Journal of Medicine·S I TaylorP Gorden
Feb 12, 1981·Nature·H A DrexhageD Doniach

❮ Previous
Next ❯


Mar 10, 2001·American Journal of Medical Genetics·F Salamanca-GómezF Salamanca-Buentello
Jun 1, 1991·Diabetes/metabolism Reviews·T J Wilkin
Nov 1, 1993·Journal of Clinical Immunology·L L WilliamsF S Wright
Nov 1, 1996·Clinical Rheumatology·A P AndonopoulosA G Vagenakis
Aug 11, 2011·Cell Biochemistry and Biophysics·Li ShaoHua Zhang
Oct 1, 1994·Pharmacology & Therapeutics·J Baselga, J Mendelsohn
Jul 1, 1996·Molecular Medicine Today·O WinqvistO Kämpe
Jan 31, 1998·Clinica Chimica Acta; International Journal of Clinical Chemistry·C MassartB Genetet
Aug 22, 2003·Thyroid : Official Journal of the American Thyroid Association·Su-Chin HoDaphne H Khoo
Apr 1, 1995·Thyroid : Official Journal of the American Thyroid Association·R M CuddihyR S Bahn
Jul 1, 1993·Clinical Endocrinology·C BetterleA Caretto
Apr 28, 2006·Annales d'endocrinologie·C Betterle
Apr 1, 1992·Clinical Biochemistry·S S Levinson
Jul 1, 1992·Clinical Immunology and Immunopathology·L L WilliamsF H Davidorf
Jan 1, 1994·Thyroid : Official Journal of the American Thyroid Association·E ResetkovaR Volpé
Jun 3, 2004·The Journal of Clinical Investigation·Takao AndoTerry F Davies
Aug 14, 1997·Annals of the New York Academy of Sciences·P M Moore
May 1, 1992·Annals of Clinical Biochemistry·S de RaveH M Goldschmidt

❮ Previous
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