PMID: 9658286Jul 11, 1998Paper

Receptor autoradiographic mapping of the mesial motor and premotor cortex of the macaque monkey

The Journal of Comparative Neurology
S GeyerKarl Zilles

Abstract

This study analyzes regional and laminar distribution patterns of neurotransmitter binding sites in the motor areas of the macaque mesial frontal cortex. Differences in distribution patterns are compared with the cytoarchitectonic parcellation. Binding sites were analyzed with quantitative in vitro receptor autoradiography in unfixed brains of five macaque monkeys. Alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA), kainate, and N-methyl-D-aspartate (NMDA) binding sites were labeled with [3H]AMPA, [3H]kainate, and [3H]MK-801, respectively, muscarinic binding sites with [3H]pirenzepine or [3H]oxotremorine-M, noradrenergic binding sites with [3H]prazosin or [3H]UK-14304, gamma-aminobutyric acid (GABA)A binding sites with [3H]muscimol, and serotoninergic binding sites with [3H]ketanserine. Adjacent sections were stained with a modified Nissl method for cytoarchitectonic analysis. In the motor areas F1, F3, and F6, [3H]AMPA, [3H]pirenzepine, and [3H]oxotremorine-M binding was maximal in layers II, III, and V, and [3H]kainate binding was maximal in layers V and VI. Clear-cut changes in laminar distribution patterns of [3H]AMPA, [3H]kainate, and [3H]oxotremorine-M binding sites very closely matched corresponding cytoarc...Continue Reading

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Citations

Mar 7, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K E StephanR Kötter
Feb 28, 2004·Microscopy Research and Technique·O SchmittS Preusse
Sep 14, 2014·Cerebral Cortex·Emmanuel ProcykCéline Amiez
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Apr 30, 2019·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Girish BathlaAndrei I Holodny
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Apr 18, 2021·The European Journal of Neuroscience·Laurence T Hunt
Feb 4, 2021·Annual Review of Neuroscience·Rogier B MarsMatthew F S Rushworth

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