PMID: 7011734Mar 1, 1981Paper

Receptor binding of biosynthetic human insulin on isolated pig hepatocytes

Diabetes Care
S Gammeltoft

Abstract

Biosynthetic human insulin (BHI) and pancreatic human insulin were compared with respect to receptor binding in a heterologous assay system: displacement of pork A14-125I-monoiodoinsulin from receptors on pig hepatocytes. The concentrations of human insulin giving half-maximal displacement were identical for both preparations, i.e., 0.5 nM. Their relative potency was 1.01 +/- 0.14 (SD, N = 5), suggesting that biosynthetic and pancreatic human insulin exert the same biologic activity.

Citations

Apr 24, 2014·Nature Chemistry·Samudra SenguptaAyusman Sen

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