PMID: 8964604Jan 1, 1996Paper

Receptor-binding properties of the peptides corresponding to the beta-endorphin-like sequence of human immunoglobulin G

Immunology Letters
V P Zav'yalovY V Mitin

Abstract

The decapeptide H2N-Ser-Leu-Thr-Cys-Leu-Val-Lys-Gly-Phe-Tyr-COOH (termed immunorphin) corresponding to the sequence 364-373 of the CH3 domain of the human immunoglobulin G1 Eu heavy chain and displaying a 43% identity with the antigenic determinant of beta-endorphin was synthesized. Immunorphin was found to compete with 125I-beta-endorphin for high-affinity receptors on murine peritoneal macrophages (K = 2.5 +/- 0.9 x 10(-9) M) and with 3H-morphin for receptors on murine thymocytes (Ki = 2.7 +/- 0.6 x 10(-9) M) and murine macrophages (Ki = 5.9 +/- 0.7 x 10(-9) M). In particular two types of receptors to 125I-beta-endorphin with Kd1 = 6.1 +/- 0.6 x 10(-9) M and Kd2 = 3.1 +/- 0.2 x 10(-8) M were revealed on macrophages. The second type of receptors interacted with 125I-beta-endorphin, 3H-Met-enkephalin, 3H-Leu-enkephalin and 3H-morphin; the first displayed reactivity with 125I-beta-endorphin, 3H-morphin and immunorphin. The first type receptors are not present on murine brain cells nor are inhibited by naloxone. A minimum fragment of immunorphin practically completely retaining its inhibitory activity in the competition tests with 125I-beta-endorphin for common receptors on thymocytes was found to correspond to the tetrapeptide H...Continue Reading

References

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Citations

May 19, 2011·Biochemistry. Biokhimii︠a︡·Yu A Kovalitskaya, E V Navolotskaya
Jun 7, 2011·Biochemistry. Biokhimii︠a︡·Yu A KovalitskayaE V Navolotskaya
Feb 12, 2014·Biochemistry. Biokhimii︠a︡·E V Navolotskaya
Jul 12, 2008·Journal of Peptide Science : an Official Publication of the European Peptide Society·Elena V NavolotskayaVladimir B Sadovnikov
Nov 5, 2011·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yulia N NekrasovaElena V Navolotskaya
May 18, 2010·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yuliia N NekrasovaElena V Navolotskaya
Apr 10, 2003·Biochemical and Biophysical Research Communications·E V NavolotskayaV M Lipkin
Nov 11, 2010·Bioorganicheskaia khimiia·Iu N NekrasovaE V Navolotskaia
Jan 15, 2016·Bioorganicheskaia khimiia·E V Navolotskaya

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