PMID: 11902863Mar 21, 2002Paper

Receptor-bound conformation of an alpha(5)beta(1) integrin antagonist by (15)N-edited 2D transferred nuclear overhauser effects

Journal of the American Chemical Society
Li ZhangMurray Goodman

Abstract

We report the results of (15)N-edited 2D transferred NOE experiments of the partially (15)N-labeled alpha(5)beta(1) antagonist c[Mpa(15)N-Arg-(15)N-Gly-(15)N-Asp-(15)N-Asp-(15)N-Val-Cys]-NH(2) (Mpa denotes mercaptopropionic acid) in the presence of the native alpha(5)beta(1) receptor. The alpha(5)beta(1) integrin receptor is believed to be involved in tumor metastasis and the rational design of alpha(5)beta(1) integrin antagonist is therefore of considerable interest. Our experiments provide insight into the alpha(5)beta(1) receptor-bound conformation of the antagonist c[MpaRGDDVC]-NH2 and will be important for the design of novel antagonists.

References

Nov 1, 1977·Angewandte Chemie·R J Williams
Jan 1, 1991·The Journal of Clinical Investigation·E Ruoslahti
Mar 1, 1988·The Journal of Cell Biology·K R GehlsenE Ruoslahti
Oct 23, 1987·Science·E Ruoslahti, M D Pierschbacher
Jan 1, 1996·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·E Ruoslahti
Feb 21, 1997·The Journal of Biological Chemistry·K SuehiroE F Plow

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Citations

Jan 13, 2005·Chembiochem : a European Journal of Chemical Biology·Dunja ZimmermannNorbert Sewald

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