Receptor characteristics and recovery of function following kainic acid lesions and fetal transplants of the striatum. I. Cholinergic systems

Brain Research
A W DeckelR G Robinson

Abstract

The relationship between striatal muscarinic cholinergic receptor development and locomotor activity/T-maze alternation behavior in adult female rats with kainic acid lesions (kal) and fetal transplants of the striatum (str) was examined. Kal led to a number of deficits under conditions of spontaneous locomotion, including: (1) decreased stereotypical and increased horizontal movements during spontaneous overnight locomotion, (2) decreased spontaneous alternation on a T-maze, and (3) deficits on a sensorimotor neurological exam. Lesion-induced deficits following injection with cholinergic agonists (pilocarpine)/antagonists (scopolamine) included: (1) hypoactivity on vertical activity and stereotypical activity following scopolamine injection, and (2) increased stereotypical activity and decreased horizontal activity following pilocarpine injection. Transplants differentially affected the different types of behavioral deficits. Transplants reversed some of the deficits under conditions of spontaneous locomotion, including the hyperactivity noted during the night period, but only partially reversed the sensorimotor neurological exam and had no effect on spontaneous alternations in the T-maze. The transplants did not reverse the l...Continue Reading

References

Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·O IsacsonA Björklund
Jan 1, 1987·Annals of the New York Academy of Sciences·A W Deckel, R G Robinson
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Citations

Sep 1, 1990·Pharmacology, Biochemistry, and Behavior·S Y LuP R Sanberg
Jan 1, 1994·Behavioral and Neural Biology·R W RussellF Bermúdez-Rattoni
Nov 22, 2000·Brain Research. Brain Research Reviews·F CicchettiA Parent
Dec 19, 2014·Frontiers in Cellular Neuroscience·Amy E ReddingtonStephen B Dunnett

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