PMID: 9444938Jan 28, 1998Paper

Receptor-Ck-dependent regulation of genes in HL-60 cell line

Leukemia Research
D Kaul, M Kaur

Abstract

The selective and conspicuous absence of a novel receptor-Ck (having affinity for cholesterol moiety in lipoproteins and intrinsic tyrosine kinase activity) in various leukemic cell lines/patients, prompted us to explore the nature of interrelationship between receptor-Ck deficiency and over-expression of genes coding for bcl-2, cyclin 'D', chimeric bcr-abl, c-myc and LDL-receptor in the human promyelocytic leukemic cell line (HL-60). This study revealed unambiguously that deregulated expression of these genes is primarily due to the inability of these cells to express the receptor-Ck gene. Based upon the observations we propose that 'receptor-Ck' deficiency may be responsible for the initiation of chronic myeloid leukemia.

References

Jan 1, 1992·Progress in Lipid Research·T Sato, J Sunamoto
Feb 1, 1990·Nature·J L Goldstein, M S Brown
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·Y Tsujimoto, C M Croce
Sep 11, 1986·Nature·W H MoolenaarS W de Laat
Jun 7, 1996·Molecular and Cellular Biochemistry·D KaulM Kaur
Dec 6, 1996·Science·C J Sherr
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Jan 30, 1997·Cancer Letters·D Kaul, J Singh
Apr 1, 1997·Molecular and Cellular Biochemistry·R GoelD Kaul

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Citations

Jul 4, 1998·Leukemia Research·D Kaul
Mar 10, 1999·Leukemia Research·D Kaul, N Varma

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