PMID: 15383554Sep 24, 2004Paper

Receptor editing in positive and negative selection of B lymphopoiesis

The Journal of Immunology : Official Journal of the American Association of Immunologists
Efrat Edry, Doron Melamed

Abstract

In B lymphopoiesis, Ag receptor expression and signaling are critical to determine developmental progression, survival, and activation. Several positive and negative selection checkpoints to test this receptor have been described in B lymphopoiesis, aiming to ensure the generation of functionally competent, nonautoimmune repertoire. Secondary Ag receptor gene recombination allows B lymphocytes to replace an inappropriate receptor with a new receptor, a mechanism called receptor editing. This salvage mechanism uncouples the Ag receptor fate from that of the cell itself, suggesting that B cell repertoire is regulated by a process of receptor selection. Secondary rearrangements are stimulated in different stages of B cell development, where editing of the receptor is necessary to fulfill stage-specific requirements. In this study, we discuss the contribution of receptor editing in B lymphopoiesis and its regulation by positive and negative selection signals.

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Citations

Jun 27, 2007·Molecular and Cellular Biology·Li BaiDemin Wang
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Efrat EdryDoron Melamed
May 3, 2007·European Journal of Immunology·Hilla Azulay-DebbyDoron Melamed
Sep 1, 2012·Blood·Doron Melamed, David W Scott
Aug 2, 2014·PloS One·Yingchi ZhangWeiping Yuan
Jun 30, 2006·Hormone Research·S BallottiM de Martino
Oct 23, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mei YuDemin Wang
May 12, 2017·Journal of Immunology Research·Darel MartínezAna María Hernández
Aug 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rostislav NovakDoron Melamed
Mar 23, 2012·Immunological Reviews·Mary Kaileh, Ranjan Sen
Jan 18, 2019·The Journal of Experimental Medicine·José M Carballido, Pere Santamaria
Apr 17, 2020·Frontiers in Immunology·José M CarballidoMichael Kammüller
May 15, 2007·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Efrat Edry, Doron Melamed
Sep 3, 2021·International Journal of Radiation Oncology, Biology, Physics·Ida Franiak-PietrygaAndrew B Sharabi

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