Receptor for advanced glycation end-product antagonist reduces blood-brain barrier damage after intracerebral hemorrhage

Stroke; a Journal of Cerebral Circulation
Fan YangHua Feng

Abstract

To determine whether the receptor for advanced glycation end-products (RAGE) plays a role in early brain injury from intracerebral hemorrhage (ICH), RAGE expression and activation after injury were examined in a rat model of ICH with or without administration of a RAGE-specific antagonist (FPS-ZM1). Autologous arterial blood was injected into the basal ganglia of rats to induce ICH. The motor function of the rats was examined, and water content was detected after euthanization. Blood-brain barrier permeability was determined by Evans blue staining and colloidal gold nanoparticle tracers. Nerve fiber injury in white matter was determined by diffusion tensor imaging analysis, and the expression of target genes was analyzed by Western blotting and quantitative reverse transcription polymerase chain reaction. FPS-ZM1 was administered by intraperitoneal injection. Expression of RAGE and its ligand high-mobility group protein B1 were increased at 12 hours after ICH, along with blood-brain barrier permeability and perihematomal nerve fiber injury. RAGE and nuclear factor-κB p65 upregulation were also observed when FeCl2 was infused into the basal ganglia at 24 hours. FPS-ZM1 administration resulted in significant improvements of blood...Continue Reading

References

Jun 11, 2003·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Kenneth R WagnerJoseph F Clark
Nov 15, 2003·Stroke; a Journal of Cerebral Circulation·Jimin WuGuohua Xi
Sep 21, 2007·Annals of Neurology·Oliver C SingerUNKNOWN MR Stroke Study Group Investigators
Dec 1, 2007·Journal of Magnetic Resonance Imaging : JMRI·Jeffrey J Neil
Nov 14, 2008·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sajjad MuhammadMarkus Schwaninger
Dec 11, 2008·Acta Neurochirurgica. Supplement·R F KeepJ T Hoff
Feb 13, 2010·Mediators of Inflammation·Weiyu TengChao Guan
Mar 26, 2011·The American Journal of Pathology·Che-Feng ChangSong-Kun Shyue
Apr 30, 2011·Stroke; a Journal of Cerebral Circulation·Jaroslaw Aronowski, Xiurong Zhao
Sep 24, 2011·Stroke; a Journal of Cerebral Circulation·Yi Yang, Gary A Rosenberg
Dec 14, 2011·Journal of Magnetic Resonance·Peter J Basser, Carlo Pierpaoli
Dec 23, 2011·Annals of Neurology·Qingyi MaJiping Tang
Dec 29, 2011·Neurochemistry International·Tomoya KamideOsamu Hori
Mar 13, 2012·The Journal of Clinical Investigation·Rashid DeaneBerislav V Zlokovic
May 11, 2012·Future Medicinal Chemistry·Richard J Deane
Aug 24, 2012·Annals of Neurology·Yu OkumaMasahiro Nishibori
Jan 5, 2013·Stroke; a Journal of Cerebral Circulation·So Yoon AhnWon Soon Park
Feb 19, 2013·Journal of Neuroinflammation·Huang FangQing-Wu Yang
Jun 5, 2013·Stroke; a Journal of Cerebral Circulation·Wendy C Ziai
Oct 2, 2013·The Journal of Experimental Medicine·Cherilyn M SiroisEicke Latz
Nov 1, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Linnea R VosePraveen Ballabh
Dec 3, 2013·Progress in Neurobiology·Yu ZhouQing-Wu Yang
Feb 15, 2014·Clinics in Perinatology·Manon J N L BendersLinda S de Vries
Mar 8, 2014·Neuroimmunomodulation·Anton GlasnovićDanka Grčević
Apr 30, 2014·The Journal of Experimental Medicine·Laure Yatime, Gregers Rom Andersen
May 23, 2014·Diabetes/metabolism Research and Reviews·Hang HuChunmao Han

❮ Previous
Next ❯

Citations

Jun 1, 2016·Frontiers in Cellular Neuroscience·Judyta K JuranekAnn Marie Schmidt
Jan 25, 2017·Behavioural Brain Research·Chengmei ShiXiangyang Guo
Dec 23, 2016·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Srijita DharMichael A Hill
Sep 5, 2020·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Vijayasree V GiridharanTatiana Barichello
Sep 12, 2017·Frontiers in Human Neuroscience·Chuanyuan TaoChao You
Jul 7, 2017·BioMed Research International·Shilun ZuoHua Feng
Aug 20, 2017·Scientific Reports·Juciano GasparottoDaniel Pens Gelain
Nov 7, 2017·Annual Review of Medicine·Barry I Hudson, Marc E Lippman
Dec 8, 2020·Frontiers in Cellular Neuroscience·María Lacalle-AuriolesThomas M Durcan
Apr 4, 2021·Cells·Haruki Watanabe, Myoungsun Son
May 9, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Nannan LiuGuanhua Du
Jun 29, 2021·Frontiers in Neurology·Xiongjie FuGao Chen

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.

Blood Brain Barrier & Cytokines

Some cytokines are able to cross the blood brain barrier through transport systems and enter the cerebrospinal fluid and interstitial fluid spaces. Here is the latest research on cytokines crossing the blood brain barrier and how this can affect tissues within the CNS.

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.