Receptor for advanced glycation end products in donor lungs is associated with primary graft dysfunction after lung transplantation.

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
A PelaezP O Mitchell

Abstract

Development of primary graft dysfunction (PGD) is associated with poor outcomes after transplantation. We hypothesized that Receptor for Advanced Glycation End-products (RAGE) levels in donor lungs is associated with the development of PGD. Furthermore, we hypothesized that RAGE levels would be increased with PGD in recipients after transplantation. We measured RAGE in bronchoalveolar lavage fluid (BALf) from 25 donors and 34 recipients. RAGE was also detected in biopsies (transbronchial biopsy) from recipients with and without PGD. RAGE levels were significantly higher in donor lungs that subsequently developed sustained PGD versus transplanted lungs that did not display PGD. Donor RAGE level was a predictor of recipient PGD (odds ratio = 1.768 per 0.25 ng/mL increase in donor RAGE level). In addition, RAGE levels remained high for 14 days in those recipients that developed severe graft dysfunction. Recipients may be at higher risk for developing PGD if they receive transplanted organs that have higher levels of soluble RAGE prior to explantation. Moreover, the clinical and pathologic abnormalities associated with PGD posttransplantation are associated with increased RAGE expression. These findings also raise the possibility t...Continue Reading

References

Jan 1, 1989·Paediatric and Perinatal Epidemiology·T BjerkedalD W Hosmer
Sep 23, 1997·Biochemical and Biophysical Research Communications·F KatsuokaK Yamashita
Jul 23, 1998·Chest·J D ChristieR M Kotloff
Mar 2, 1999·American Journal of Respiratory and Critical Care Medicine·L B WareM A Matthay
Mar 11, 2000·American Journal of Respiratory and Critical Care Medicine·V NewmanL G Dobbs
Jul 13, 2000·The Annals of Thoracic Surgery·R C KingI L Kron
Feb 24, 2001·American Journal of Respiratory and Critical Care Medicine·A J FisherP A Corris
May 24, 2001·American Journal of Respiratory and Critical Care Medicine·L B Ware, M A Matthay
Feb 18, 2003·American Journal of Respiratory and Critical Care Medicine·Marc de PerrotShaf Keshavjee
Oct 14, 2003·Chest·Jason D ChristieStephen E Kimmel
Mar 11, 2004·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Madoka ShirasawaYutaka Hata
Oct 2, 2004·The European Respiratory Journal·M C McElroy, M Kasper
Mar 15, 2005·American Journal of Respiratory and Critical Care Medicine·Jason D ChristieStephen E Kimmel
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Jason D ChristieUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Selim M ArcasoyUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Oct 8, 2005·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Yaron ShargallUNKNOWN ISHLT Working Group on Primary Lung Graft Dysfunction
Feb 4, 2006·American Journal of Respiratory and Critical Care Medicine·Tokujiro UchidaMichael A Matthay
Feb 14, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·H KanedaS Keshavjee
Jun 27, 2006·American Journal of Respiratory and Critical Care Medicine·Luis F AngelStephanie M Levine
Dec 1, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christopher M BurtonClaus B Andersen
Mar 14, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·James A FrankMichael A Matthay
May 8, 2007·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Katharina KrennSeyedhossein Aharinejad
Jul 7, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Carolyn S CalfeeAlejandro C Arroliga
Sep 12, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M RayG A Patterson
Oct 24, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mei HeMutsuo Yamaya
Jun 7, 2008·American Journal of Respiratory and Critical Care Medicine·Haiying ZhangAkitoshi Ishizaka
Aug 30, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·M AnrakuS Keshavjee
Oct 31, 2008·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Priyumvada M NaikAndres Pelaez
Nov 21, 2008·Thorax·Mark J D Griffiths, Danny F McAuley
Dec 31, 2008·The Journal of Thoracic and Cardiovascular Surgery·David I SternbergJoshua R Sonett
Jan 13, 2009·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Andres PelaezE Clinton Lawrence
Aug 8, 2009·American Journal of Respiratory and Critical Care Medicine·Jason D ChristieUNKNOWN Lung Transplant Outcomes Group

❮ Previous
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Citations

Jan 25, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naoko YamakawaKoshi Makita
Jul 16, 2014·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Enjarn LinPaul S Myles
Apr 16, 2011·Seminars in Immunopathology·Priyumvada M Naik, Luis F Angel
Jul 4, 2013·Seminars in Respiratory and Critical Care Medicine·Yoshikazu SuzukiJason D Christie
Oct 14, 2014·The American Journal of the Medical Sciences·Andres PelaezDavid M Guidot
Dec 2, 2014·The American Journal of Pathology·Leslie A MitchellMichael Koval
Jun 15, 2012·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Rupal J ShahJason D Christie
Apr 23, 2011·Clinics in Chest Medicine·James C Lee, Jason D Christie
Jan 22, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R J ShahJ D Christie
Jul 31, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Julien PottecherPierre Diemunsch
Mar 26, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giuseppina BastaFranco Filipponi
May 17, 2011·Alcoholism, Clinical and Experimental Research·Xian FanDavid M Guidot
Jan 12, 2017·Expert Review of Respiratory Medicine·Ciara M Shaver, Lorraine B Ware
Jan 29, 2017·American Journal of Physiology. Lung Cellular and Molecular Physiology·B C S HamiltonM A Matthay
Aug 10, 2010·Current Opinion in Organ Transplantation·Joshua M Diamond, Jason D Christie
Sep 3, 2013·Current Opinion in Organ Transplantation·Joshua M Diamond, Christopher H Wigfield
Aug 9, 2016·Transplantation·Julien PottecherUNKNOWN Groupe de Transplantation Pulmonaire des Hôpitaux Universitaires de Strasbourg
Sep 6, 2017·American Journal of Respiratory and Critical Care Medicine·Edward CantuUNKNOWN Lung Transplant Outcomes Group
Aug 12, 2015·Current Opinion in Organ Transplantation·Mary K PorteousJason D Christie
Jan 30, 2018·Clinical Transplantation·Barbara C S HamiltonJasleen Kukreja
May 25, 2021·Seminars in Respiratory and Critical Care Medicine·Jake G Natalini, Joshua M Diamond

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