Receptor for advanced glycation end products in bacterial infection: is there a role for immune modulation of receptor for advanced glycation end products in the treatment of sepsis?

Current Opinion in Infectious Diseases
Eirini ChristakiSteven M Opal

Abstract

Sepsis is still associated with excess morbidity and mortality worldwide, despite significant advances in critical care medicine. A novel approach is needed in the treatment of sepsis, one that will aim to correct the specific immunologic imbalance that is detrimental to the septic host. As receptor for advanced glycation end products (RAGE) is involved in diverse cellular mechanisms that to a lesser or greater extent participate in the septic process, modulating its function could favorably affect outcome. Altering RAGE may result in regulating the release of proinflammatory cytokines, controlling apoptosis or modifying endothelial architecture. In that regard, several strategies have been used to study RAGE deficiency in experimental models of sepsis including antibodies against RAGE, genetically deleted RAGE knockouts, siRNA to silence RAGE, soluble forms of RAGE, and antibodies and inhibitors directed toward RAGE ligands, such as HMGB1 and S100 proteins. These studies thus far have yielded inconsistent results as to whether RAGE is beneficial or not to the host response during bacterial infection and sepsis.

References

Dec 29, 2000·Seminars in Thrombosis and Hemostasis·A M SchmidtD M Stern
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Sep 1, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angelika BierhausPeter P Nawroth
Oct 18, 2005·Trends in Cardiovascular Medicine·Ravichandran RamasamyAnn Marie Schmidt
Jul 31, 2007·The EMBO Journal·Thorsten OstendorpGünter Fritz
Nov 6, 2007·The Journal of Surgical Research·Christian BoppMarkus A Weigand
Nov 29, 2007·Critical Care : the Official Journal of the Critical Care Forum·Emily C LutterlohNoubar Kessimian
Jan 30, 2008·Critical Care : the Official Journal of the Critical Care Forum·Christian BoppMarkus A Weigand
Jul 8, 2008·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Angela RaucciMarco E Bianchi
Aug 1, 2008·The Journal of Biological Chemistry·Jingjing XieAlexander Shekhtman
Jan 24, 2009·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anastasia Z KaleaBarry I Hudson
Mar 12, 2009·Current Medicinal Chemistry·Francesca SantilliGiovanni Davì
Mar 21, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marieke A D van ZoelenTom van der Poll
Jul 25, 2009·The Journal of Infectious Diseases·Marieke A D van ZoelenTom van der Poll
Feb 11, 2010·Journal of Biomedicine & Biotechnology·Stephen T Buckley, Carsten Ehrhardt
Dec 15, 2010·Microvascular Research·Rachel K WolfsonJoe G N Garcia
Jan 25, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Naoko YamakawaKoshi Makita
Jan 29, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yasuhiko YamamotoHiroshi Yamamoto
May 14, 2011·Structure·Jing XueAlexander Shekhtman
Sep 17, 2011·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·G TakahashiS Endo
Oct 21, 2011·American Journal of Physiology. Cell Physiology·Jean-Marc TadiéEdward Abraham

❮ Previous
Next ❯

Citations

Mar 26, 2016·Parasite : Journal De La Société Française De Parasitologie·Karim TraoréStéphane Picot
Oct 4, 2013·Mediators of Inflammation·Benedict C Creagh-BrownAnne Burke-Gaffney
Oct 8, 2016·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·Chunyan YangHui Wang
Aug 2, 2017·The Journal of International Medical Research·Xin ZhaoQian Huang
Mar 5, 2016·Scientific Reports·Michaele B ManigrassoAnn Marie Schmidt
Mar 15, 2016·Journal of Periodontal Research·M B GrauballeP Holmstrup
Nov 13, 2015·Expert Opinion on Therapeutic Targets·Ravichandran RamasamyAnn Marie Schmidt

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis