Receptor for AGEs (RAGE) blockade may exert its renoprotective effects in patients with diabetic nephropathy via induction of the angiotensin II type 2 (AT2) receptor.

Diabetologia
Karly C SourrisJosephine M Forbes

Abstract

The receptor for AGEs (RAGE) contributes to the development and progression of diabetic nephropathy. In this study, we examined whether the protective effects of RAGE blockade are exerted via modulation of the renal angiotensin II type 2 (AT2) receptor. Control and streptozotocin diabetic mice, wild-type or deficient in the AT2 receptor (At2 knockout [KO]) or RAGE (Rage KO), were studied for 24 weeks. Adenoviral overexpression of full-length Rage in primary rat mesangial cells was also used to determine the effects on AT2 production. With diabetes, Rage-deficient mice had less albuminuria, and an attenuation of hyperfiltration and glomerulosclerosis as compared with diabetic wild-type and At2 KO mice. Renal gene and protein expression of RAGE was elevated with diabetes. Diabetic Rage KO mice had a greater increase in renal AT2 receptor protein than was seen in diabetic wild-type mice. Diabetes-induced increases in renal cytosolic and mitochondrial superoxide generation were prevented in diabetic Rage KO mice, but enhanced in all At2 KO mice. Adenoviral overexpression of RAGE or AGE treatment decreased cell surface AT2 expression, in association with increasing superoxide generation; both were reversed using antioxidants N-acety...Continue Reading

References

Jul 15, 1997·The Journal of Clinical Investigation·H M Siragy, R M Carey
May 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·H M SiragyR M Carey
Jan 3, 2001·American Journal of Physiology. Renal Physiology·J M SaavedraI Armando
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·M P WautierJ L Wautier
May 16, 2001·Genesis : the Journal of Genetics and Development·R ConstienB Arnold
Jul 18, 2001·The Journal of Clinical Investigation·Y YamamotoH Yamamoto
Sep 22, 2001·The New England Journal of Medicine·B M BrennerUNKNOWN RENAAL Study Investigators
Apr 23, 2002·Journal of the Renin-angiotensin-aldosterone System : JRAAS·B M BrennerUNKNOWN RENAAL Study Investigators
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Zhen LiMasatsugu Horiuchi
Dec 4, 2003·The International Journal of Biochemistry & Cell Biology·Siu Wai TsangPo Sing Leung
Apr 17, 2004·Kidney International·Stephen R DunnKumar Sharma
Nov 26, 2004·Journal of the American Society of Nephrology : JASN·Matthew D BreyerUNKNOWN AMDCC
Dec 16, 2004·The Journal of Clinical Investigation·Angelika BierhausPeter P Nawroth
Jun 3, 2005·Journal of the American Society of Nephrology : JASN·Josephine M ForbesMark E Cooper
Aug 19, 2005·Journal of the American Society of Nephrology : JASN·Merlin C ThomasJosephine M Forbes
May 10, 2006·British Journal of Pharmacology·Joep H M van EschA H Jan Danser
Jun 27, 2006·Journal of Pharmacological Sciences·Mizuo Miyazaki, Shinji Takai
May 31, 2008·Diabetes·Josephine M ForbesMark E Cooper
Jan 9, 2009·American Journal of Nephrology·Christiane RüsterGunter Wolf
Jan 23, 2009·Journal of the American Society of Nephrology : JASN·Melinda T CoughlanJosephine M Forbes
May 20, 2009·Annals of Internal Medicine·Rudy BilousHans-Henrik Parving
Jul 3, 2009·The New England Journal of Medicine·Michael MauerRonald Klein

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Citations

Oct 22, 2010·Amino Acids·Josephine M Forbes, Mark E Cooper
Apr 29, 2010·Current Atherosclerosis Reports·Alan DaughertyLisa A Cassis
Jan 17, 2002·Journal of Immunological Methods·Sylvie MiotJürg Alfred Schifferli
Dec 3, 1999·The International Journal of Biochemistry & Cell Biology·P Ponka, C N Lok
May 26, 2011·Nature Reviews. Endocrinology·Helen Vlassara, Gary E Striker
Mar 5, 2011·American Journal of Nephrology·Joseph GawdzikMarion A Hofmann Bowman
Aug 19, 2011·American Journal of Nephrology·Christiane RüsterGunter Wolf
Sep 27, 2007·Critical Care : the Official Journal of the Critical Care Forum·Marcela Helena GambimMariano Janiszewski
Apr 2, 2014·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Stephen P Gray, Karin Jandeleit-Dahm
Dec 17, 2011·Free Radical Biology & Medicine·Karly C SourrisJosephine M Forbes
Apr 5, 2011·Clinical Science·Drazenka Pongrac BarlovicKarin A M Jandeleit-Dahm
Jul 11, 2013·Cellular Signalling·Jianling XieMaría Montserrat Aguilar-Hernández
Nov 22, 2017·Antioxidants & Redox Signaling·Naila Rabbani, Paul J Thornalley
Dec 31, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Stephen P GrayKarin A M Jandeleit-Dahm
Apr 9, 2013·Circulation·Stephen P GrayKarin A Jandeleit-Dahm
Aug 23, 2018·American Journal of Physiology. Renal Physiology·Michaele B ManigrassoAnn Marie Schmidt
Jul 1, 2016·Clinical Science·Bryna S M Chow, Terri J Allen
Feb 12, 2014·The Journal of Biological Chemistry·Eun Young ParkJong Hoon Park
Mar 16, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Teresita MeniniAlejandro Gugliucci
Nov 17, 2016·Mediators of Inflammation·Han WuBiao Xu
Aug 14, 2018·Archives of Pharmacal Research·Jinni HongWeiwei Li
Mar 27, 2020·International Journal of Molecular Sciences·Devang M PatelMark E Cooper
May 27, 2020·International Journal of Nephrology·Suzan A KhodirOmnia Ameen
Jan 7, 2021·International Journal of Molecular Sciences·Sara PanizoJorge B Cannata-Andía
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nutthapoom Pathomthongtaweechai, Somchai Chutipongtanate

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