Receptor for hyaluronic acid-mediated motility (RHAMM, CD168) expression is prognostically important in both nodal negative and nodal positive large cell lung cancer

Journal of Clinical Pathology
Florian AugustinAlexandar Tzankov

Abstract

Despite advances in therapy, lung cancer is still the leading cause of cancer-related mortality in the world. Further prognostic tools are warranted for risk-adapted therapeutic decisions. We analysed a cohort of primary surgically treated non-small cell lung cancers (NSCLCs) to determine the prognostic role of CD44 and associated molecules (receptor for hyaluronic acid-mediated motility (RHAMM), CD95, osteopontin (OPN), P-glycoprotein (P-gp) and caspase 3 (Casp3)). CD44 is a cell adhesion molecule. While the standard form (CD44s) is ubiquitously expressed, its variant isoforms are claimed to play an important role in invasion and metastasis in various cancers. Three-hundred and eighty-three primary surgically resected NSCLC specimens were brought into a standardised tissue microarray platform. Immunohistochemistry for CD44, CD95, RHAMM, OPN, P-gp and Casp3 was performed. The clinical correlation was made with known histopathological, phenotypical and genotypical variables; clinical data were available for a postoperative follow-up period of up to 15 years. RHAMM expression in the subgroup of large cell carcinomas (LCC) was associated with inferior survival (p=0.000223). Median overall survival was 92 versus 18 months for RHAMM...Continue Reading

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Citations

Aug 11, 2015·Frontiers in Oncology·Tamara MirzapoiazovaPatrick A Singleton
Oct 27, 2018·Molecular Carcinogenesis·Jung Min SongFekadu Kassie
May 7, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·William SterlacciAlexandar Tzankov
Aug 23, 2020·International Journal of Molecular Sciences·Jinfen WeiHongli Du
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Honglan Guo, Qinqiao Fan
Jun 9, 2021·Biomolecules & Therapeutics·You SunKyung Song

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