Abstract
Despite advances in therapy, lung cancer is still the leading cause of cancer-related mortality in the world. Further prognostic tools are warranted for risk-adapted therapeutic decisions. We analysed a cohort of primary surgically treated non-small cell lung cancers (NSCLCs) to determine the prognostic role of CD44 and associated molecules (receptor for hyaluronic acid-mediated motility (RHAMM), CD95, osteopontin (OPN), P-glycoprotein (P-gp) and caspase 3 (Casp3)). CD44 is a cell adhesion molecule. While the standard form (CD44s) is ubiquitously expressed, its variant isoforms are claimed to play an important role in invasion and metastasis in various cancers. Three-hundred and eighty-three primary surgically resected NSCLC specimens were brought into a standardised tissue microarray platform. Immunohistochemistry for CD44, CD95, RHAMM, OPN, P-gp and Casp3 was performed. The clinical correlation was made with known histopathological, phenotypical and genotypical variables; clinical data were available for a postoperative follow-up period of up to 15 years. RHAMM expression in the subgroup of large cell carcinomas (LCC) was associated with inferior survival (p=0.000223). Median overall survival was 92 versus 18 months for RHAMM...Continue Reading
References
Apr 5, 1991·Cell·U GünthertP Herrlich
Aug 30, 2005·Experimental Gerontology·Alexandar TzankovStephan Dirnhofer
Sep 17, 2005·Cell Death and Differentiation·A MielgoU Günthert
May 10, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Farin KamangarWilliam F Anderson
Apr 26, 2008·Gut·I ZlobecA Lugli
Jan 15, 2009·International Journal of Cancer. Journal International Du Cancer·Colette CharpinStéphane Garcia
Jan 20, 2009·Cancer·John M VarlottoMalcolm M Decamp
Apr 8, 2009·Cell and Tissue Research·Chi-Mou LiuLynn L H Huang
Oct 28, 2009·Experimental Hematology·Sabine NagelAlexandar Tzankov
Nov 21, 2009·Leukemia & Lymphoma·Alexandar TzankovStephan Dirnhofer
Feb 16, 2010·The Lancet Oncology·Rinat YerushalmiKaren A Gelmon
Jan 29, 2011·Annals of Hematology·Alexandar TzankovUrsula Günthert
Mar 26, 2011·BMC Cancer·Sumiya IshigamiShoji Natsugoe
Jun 10, 2011·Communicative & Integrative Biology·Patrick G TelmerEva A Turley
Aug 16, 2011·Human Pathology·William SterlacciAlexandar Tzankov
Aug 23, 2011·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·William SterlacciSpasenija Savic
Sep 3, 2011·Cancer·Andrew ChiVinata B Lokeshwar
Sep 10, 2011·Drugs·Katayoun Rezvani, Hugues de Lavallade
May 23, 2012·The Journal of International Medical Research·H SuiQ Li
Feb 2, 2013·Current Cancer Drug Targets·Ziyad Binkhathlan, Afsaneh Lavasanifar
Apr 10, 2013·BMC Cancer·Jun ShiNingli Li
Oct 2, 2013·BioMed Research International·Dragana NikitovicGeorge N Tzanakakis
Oct 8, 2013·The Annals of Thoracic Surgery·Bing-Sheng SunChang-Li Wang
Oct 25, 2013·Oncology Reports·Anna BabiakJochen Greiner
Dec 19, 2013·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Willam SterlacciAlexandar Tzankov
Jan 31, 2014·Frontiers in Oncology·Laura ZinziNicola Antonio Colabufo
Mar 29, 2014·Journal of Cancer Research and Clinical Oncology·Hideo ShigeishiMasaaki Takechi
Apr 16, 2014·Proceedings of the National Academy of Sciences of the United States of America·Mandana VeisehMina J Bissell
Citations
Aug 11, 2015·Frontiers in Oncology·Tamara MirzapoiazovaPatrick A Singleton
Oct 27, 2018·Molecular Carcinogenesis·Jung Min SongFekadu Kassie
Jul 14, 2019·Cancer Science·Taichiro YoshimotoToshiro Niki
May 17, 2018·Oncotarget·Yao-Tseng ChenYi-Chieh Nancy Du
Oct 26, 2016·Oncotarget·Dunrui WangYi-Chieh Nancy Du
May 7, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·William SterlacciAlexandar Tzankov
Mar 29, 2019·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nina Schatz-SiemersYi-Chieh Nancy Du
Jun 18, 2017·The American Journal of Surgical Pathology·Hans BlaauwgeersErik Thunnissen
Aug 23, 2020·International Journal of Molecular Sciences·Jinfen WeiHongli Du
Oct 13, 2019·Cancer Medicine·Lu ChenXiu-Wu Bian
Jul 6, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Honglan Guo, Qinqiao Fan
Jun 9, 2021·Biomolecules & Therapeutics·You SunKyung Song