PMID: 7033434Dec 1, 1981Paper

Receptor for immunoglobulin Fc on pathogenic but not on nonpathogenic protozoa of the Trypanosomatidae

The Journal of Experimental Medicine
I K De Miranda-Santos, Antonio Campos-Neto

Abstract

Members of the Trypanosomatidae were studied for their ability to acquire host IgG through a possible Fc receptor. A simple rosette test was devised in which the different species and forms of protozoa were mixed with SRBC sensitized with subagglutinating does of IgG, IgM, and F (ab') 2 anti-SRBC, and the pelleted mixture was observed for the number of clumps (rosettes) formed between the parasites and SRBC. Rosettes were formed between parasites and SRBC sensitized with IgG but not with IgM or F(ab')2, indicating the presence of a receptor for IgG Fc. The specificity of this receptor for Fc was confirmed by inhibition experiments with normal rabbit aggregated gammaglobulins or with purified normal rabbit Fc. The receptor is sensitive to treatment with trypsin but regenerates after a short period of incubation (1 h), which indicates that it is synthesized by the parasite itself. Interesting was the observation that only pathogenic members of the Trypanosomatidae formed rosettes with sensitized SRBC. In none of the nonpathogenic forms studied could we demonstrate the Fc receptor. Also important was the finding that freshly isolated blood stream forms of Trypanosoma cruzi from infected mice did not form rosettes. However, after t...Continue Reading

References

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Citations

Mar 1, 1991·Immunology Letters·M Daëron
Feb 14, 2004·Journal of Virology·Xiaoqing LinHarvey M Friedman
Feb 9, 2011·Immunogenetics·Wanessa Araújo CarvalhoIsabel K Ferreira de Miranda Santos
Jul 15, 2004·International Immunopharmacology·Matthias BudtHartmut Hengel
May 1, 1986·Scandinavian Journal of Immunology·R C WilliamsF T Koster
Oct 14, 1998·Experimental Parasitology·C M Melo CoutinhoT C Araújo-Jorge
Jul 1, 1984·Revista Do Instituto De Medicina Tropical De São Paulo·J K KloetzelE S Umezawa
Feb 1, 1985·The Journal of protozoology·A Campos-NetoA F Andrade
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·R C Williams

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