PMID: 8588223Dec 1, 1995Paper

Receptor (immunophilin-binding) assay for immunosuppressive drugs

Therapeutic Drug Monitoring
S J Soldin

Abstract

The major immunophilins that bind cyclosporine (cyclophilin) and FK-506/rapamycin (FK-BP12) have been well characterized. They possess rotamase activity, which is inhibited by the immunosuppressant that binds to them. The immunosuppressive action does not appear to be coupled to rotamase activity. The literature on some possible mechanisms of immunosuppression is reviewed. Minor immunophilins of 14, 37, and 52 kDa have also been isolated and partially characterized. The 14-kDa immunophilin binds FK-506 and rapamycin whereas the 52-kDa immunophilin binds all three drugs. Neither of these proteins have rotamase activity. Receptor assays employing immunophilins have been developed. Preliminary results are encouraging indicating that they may possess some advantages over current immunoassay procedures.

Citations

Oct 1, 1996·Clinical Biochemistry·S J Soldin
Aug 1, 1997·Clinical Biochemistry·N GoodyearS J Soldin
Dec 17, 1997·Clinical Biochemistry·N GoodyearS J Soldin
Jun 18, 1998·Clinical Biochemistry·J N MurthyS J Soldin
Jan 7, 1999·Clinical Biochemistry·J N MurthyS J Soldin
Feb 7, 2001·Clinical Biochemistry·D L DavisS J Soldin
May 24, 2000·Clinical Therapeutics·D L Davis, S J Soldin
Jan 11, 2003·Archives of Pathology & Laboratory Medicine·Steven J SoldinUNKNOWN College of American Pathologists Study

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.