Receptor-independent effects of natural cannabinoids in rat peritoneal mast cells in vitro.

Biochimica Et Biophysica Acta
J L BuebE J Tschirhart

Abstract

Cannabinoids can activate CB(1) and CB(2) receptors. Since a CB(2) mRNA has been described in rat peritoneal mast cells (RPMC), we investigated a series of cannabinoids and derivatives for their capacity to stimulate RPMC. Effects of natural cannabinoids Delta(9)-tetrahydrocannabinol (Delta(9)-THC), Delta(8)-THC, endocannabinoids (anandamide, palmitoylethanolamide) and related compounds (N-decanoyl-, N-lauroyl-, N-myristoyl-, N-stearoyl- and N-oleoyl-ethanolamines; N-palmitoyl derivatives (-butylamine, -cyclohexylamine, -isopropylamine); and N-palmitoyl, O-palmitoylethanolamine), and synthetic cannabinoids including WIN 55,212-2, SR141716A and SR144528 were assessed for their capacity to induce histamine release or prime RPMC stimulated by compound 48/80. Only Delta(9)-THC and Delta(8)-THC could induce non-lytic, energy- and concentration-dependent histamine releases from RPMC (respective EC(50) values: 23.5+/-1.2; 53.4+/-20.6 microM, and maxima: 71.2+/-5.5; 55.7+/-2.7% of the total RPMC histamine content). These were not blocked by CB(1) (SR141716A) or CB(2) (SR144528) antagonists, but reduced by pertussis toxin (100 ng/ml). Endocannabinoids and analogues did neither induce histamine secretion, nor prime secretion induced by c...Continue Reading

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Citations

Jan 16, 2002·European Journal of Pharmacology·Xavier Ferry, Yves Landry
Mar 7, 2003·European Journal of Pharmacology·Alaster H Y Lau, Sharron S M Chow
Aug 2, 2008·Clinical and Experimental Pharmacology & Physiology·Scott D Smid
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Jul 19, 2005·Journal of Neuroimmunology·J Ludovic Croxford, Takashi Yamamura
May 9, 2008·Journal of Neuroendocrinology·D De FilippisT Iuvone
Jun 5, 2013·International Immunopharmacology·Jae-Myung YooMee Ree Kim
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Mar 22, 2003·Clinical Pharmacokinetics·Franjo Grotenhermen
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Jan 10, 2012·The Journal of Allergy and Clinical Immunology·Koji SugawaraRalf Paus
May 24, 2019·Medical Cannabis and Cannabinoids·Petra Luschnig, Rudolf Schicho

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