Receptor-interacting protein kinase 1 (RIPK1) as a therapeutic target.

Nature Reviews. Drug Discovery
Lauren MifflinJunying Yuan

Abstract

Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) is a key mediator of cell death and inflammation. The unique hydrophobic pocket in the allosteric regulatory domain of RIPK1 has enabled the development of highly selective small-molecule inhibitors of its kinase activity, which have demonstrated safety in preclinical models and clinical trials. Potential applications of these RIPK1 inhibitors for the treatment of monogenic and polygenic autoimmune, inflammatory, neurodegenerative, ischaemic and acute conditions, such as sepsis, are emerging. This article reviews RIPK1 biology and disease-associated mutations in RIPK1 signalling pathways, highlighting clinical trials of RIPK1 inhibitors and potential strategies to mitigate development challenges.

References

Jul 27, 2000·Molecular Cell·M Schmidt-SupprianM Pasparakis
Aug 26, 2004·Molecular Cell·Atsuhiro KanayamaZhijian J Chen
Jan 13, 2006·Nature Chemical Biology·Alexei DegterevJunying Yuan
Jul 26, 2006·Journal of Human Genetics·Takeshi AokiEmiko Noguchi
Aug 16, 2006·Neuro-degenerative Diseases·Andreas PapassotiropoulosRoger M Nitsch
Oct 19, 2006·Science's STKE : Signal Transduction Knowledge Environment·Hans Häcker, Michael Karin
Feb 3, 2007·Bioorganic & Medicinal Chemistry Letters·Ke WangChengye Yuan
Apr 21, 2007·Neurochemical Research·Jason D Hinman, Carmela R Abraham
Feb 7, 2008·Inflammatory Bowel Diseases·Martina E SpehlmannStefan Schreiber
Apr 15, 2008·Nature Chemical Biology·Alexei DegterevJunying Yuan
May 22, 2008·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zerong YouMichael J Whalen
Sep 5, 2008·Bioorganic & Medicinal Chemistry Letters·Weihong ZhengChengye Yuan
Jan 27, 2009·Nature Genetics·Rajan P NairUNKNOWN Collaborative Association Study of Psoriasis
Apr 30, 2010·Nature·Hirofumi MaruyamaHideshi Kawakami
May 25, 2010·American Journal of Human Genetics·Bernard ThienpontLars Allan Larsen
Jun 10, 2010·The Journal of Experimental Medicine·Lars VereeckeGeert van Loo
Jul 28, 2010·Proceedings of the National Academy of Sciences of the United States of America·Marta M LipinskiJunying Yuan
Feb 18, 2011·Genes and Immunity·S L MusoneL A Criswell
Feb 22, 2011·Nature Genetics·Indra AdriantoPatrick M Gaffney
Feb 23, 2011·European Journal of Immunology·Nadine HövelmeyerAri Waisman
Nov 16, 2011·Archives of Neurology·Faisal FectoTeepu Siddique
Nov 25, 2011·The Journal of Investigative Dermatology·Trilokraj TejasviRajan P Nair
Dec 23, 2011·Annals of Neurology·Nikolaos A PatsopoulosPaul I W de Bakker

❮ Previous
Next ❯

Citations

Sep 30, 2020·Nature Metabolism·Nicholas John Timpson
Dec 1, 2020·Expert Opinion on Therapeutic Patents·Philip A Harris
Dec 29, 2020·Frontiers in Cell and Developmental Biology·Kaijiang XiaSudan He
Jan 14, 2021·The EMBO Journal·Matthias Kist, Domagoj Vucic
Feb 12, 2021·Acta Neuropathologica·Carmen PiconRichard Reynolds
Feb 12, 2021·Cancers·Laura Della TorreLucia Altucci
Dec 5, 2020·Cell Death and Differentiation·Theresa RiebelingStefan Krautwald
Feb 21, 2021·Bioorganic & Medicinal Chemistry Letters·Jiamin ZhengGe Zou
Mar 12, 2021·Atherosclerosis·Isabelle CoornaertWim Martinet
Mar 18, 2021·European Journal of Medicinal Chemistry·Shuwei WuXiaohu Zhang
Mar 27, 2021·Proceedings of the National Academy of Sciences of the United States of America·Lauren MifflinChengyu Zou
Apr 4, 2021·International Journal of Molecular Sciences·Ming-Hui YangYu-Chang Tyan
Apr 30, 2021·The Journal of Cell Biology·Xinyue HuangJunying Yuan
May 1, 2021·Biomolecules·Mary SpeirKate E Lawlor
May 1, 2021·European Journal of Medicinal Chemistry·Chunnian XiaChunlin Zhuang
May 9, 2021·Bioorganic & Medicinal Chemistry Letters·Jing ZhuChunlin Zhuang
May 1, 2021·Journal of Neurochemistry·Xiao-Ming WangQing Tian
Jun 3, 2021·Cell Discovery·Huyan MengYing Li
Jun 3, 2021·Experimental & Molecular Medicine·Jinho SeoJaewhan Song
Jun 25, 2021·Frontiers in Immunology·Jiahui ZhangQing Zhou
Jul 6, 2021·RSC Medicinal Chemistry·Silke Miller, Maria-Jesus Blanco
Jul 23, 2021·Journal of Proteome Research·Dong-Gi MunAkhilesh Pandey
Jul 5, 2021·Trends in Immunology·Rajendra Karki, Thirumala-Devi Kanneganti
Jul 31, 2021·BMC Biology·Timothy J Mitchison
Aug 8, 2021·Cells·Grant R Campbell, Stephen A Spector
Aug 28, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Qiong WangCheng Xiao
Sep 1, 2021·Mucosal Immunology·Kenta MoriwakiFrancis K M Chan
Aug 31, 2021·RSC Chemical Biology·Robert B A Quinlan, Paul E Brennan
Aug 30, 2021·Methods : a Companion to Methods in Enzymology·Sovan SahaSubhadip Basu
Sep 14, 2021·GeroScience·Nidheesh ThadathilSathyaseelan S Deepa
Sep 21, 2021·Frontiers in Immunology·Ana Águeda-PintoPedro J Esteves
Oct 10, 2021·Acta Neuropathologica Communications·Anusha JayaramanRichard Reynolds
Sep 30, 2021·Journal of the European Academy of Dermatology and Venereology : JEADV·C BraegelmannJ Wenzel
Oct 29, 2021·Journal of Toxicology and Environmental Health. Part a·Manigandan NagarajanJeganathan Manivannan
Nov 12, 2021·Aging Cell·Sabira MohammedSathyaseelan S Deepa

❮ Previous
Next ❯

Methods Mentioned

BETA
IECs
IEC

Clinical Trials Mentioned

NCT02903966
NCT02858492
NCT02776033
NCT04316585
NCT03681951
NCT03757351
NCT03757325

Related Concepts

Related Feeds

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Alexei DegterevJunying Yuan
Proceedings of the National Academy of Sciences of the United States of America
Yue LiDaniel Kotlarz
Seminars in Cell & Developmental Biology
Lin Liu, Najoua Lalaoui
© 2021 Meta ULC. All rights reserved