Receptor mechanisms of rapid extranuclear signalling initiated by steroid hormones

Essays in Biochemistry
Viroj Boonyaratanakornkit, Dean P Edwards

Abstract

In addition to their role as direct regulators of gene transcription mediated by classical nuclear hormone receptors, steroid hormones have also been described to exert rapid effects on intracellular signalling pathways independent of gene transcription. This chapter focuses on recent advances in our understanding of the receptors and mechanisms that mediate these rapid signalling actions of oestrogens and progesterone. Increasing evidence suggests that at least some of these rapid actions are mediated by a subpopulation of the classical nuclear oestrogen receptor (ER) and progesterone receptor (PR) that localize to the cytoplasm or associate with the plasma membrane. Human PR has been shown to mediate rapid progestin activation of the Src/Ras/Raf/mitogen-activated protein kinase signalling pathway in mammalian cells by a direct interaction with the Src homology 3 domain of Src tyrosine kinases through a Pro-Xaa-Xaa-Pro-Xaa-Arg motif located in the N-terminal domain of the receptor. Moreover, this is an extranuclear action of PR that is separable from its direct transcriptional activity. Additionally, a novel membrane protein unrelated to nuclear PR was recently identified that has properties of a G-protein-coupled receptor for...Continue Reading

Citations

Dec 28, 2006·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Anna K Sfakianaki, Errol R Norwitz
Jan 16, 2007·Molecular and Cellular Endocrinology·Eric R ProssnitzLarry A Sklar
Feb 14, 2012·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Cristie NoschangCarla Dalmaz
Sep 5, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·H Faus, B Haendler
Aug 15, 2006·The Journal of Steroid Biochemistry and Molecular Biology·Edward V YounglaiThomas M Price
Feb 9, 2011·The Journal of Steroid Biochemistry and Molecular Biology·Cheryl S WatsonJutatip Guptarak
Sep 29, 2005·Reproductive Biology and Endocrinology : RB&E·Benson T Akingbemi
May 20, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·R S Finn
Mar 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Virginie Fontaine-LenoirPaul Robel
Sep 24, 2015·PloS One·Md Babul HossainToshinobu Tokumoto
Feb 3, 2006·Biology of Reproduction·John J Peluso
Mar 24, 2015·Bioorganic & Medicinal Chemistry Letters·Hanumantharayappa BharathkumarKanchugarakoppal S Rangappa
Mar 15, 2013·Mucosal Immunology·G O Canny, B A Lessey
Mar 28, 2006·Future Oncology·Alena Pance
Sep 22, 2007·Journal of Cellular Physiology·Boris J CheskisLeonard P Freedman
Mar 23, 2005·Archives of Histology and Cytology·Robert M Brenner, Ov D Slayden
Apr 7, 2007·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Stephen N BirrellWayne D Tilley
May 31, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Atef NehdiMohamed Boudjelal
Dec 3, 2015·Current Opinion in Obstetrics & Gynecology·Rachel Louise O'DonnellRichard J Edmondson
Jul 8, 2009·The Oncologist·Deric L WheelerEmily F Dunn
Sep 3, 2011·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ronan RussellGeraldine O Canny
Dec 30, 2006·Molecular and Cellular Biology·James G GregerBoris J Cheskis
Sep 15, 2005·Endocrine Reviews·Henry N JabbourHilary O D Critchley
Oct 6, 2007·Endocrine Reviews·Stephen R Hammes, Ellis R Levin
Apr 18, 2008·Molecular Endocrinology·Suzanne D Conzen
Jul 30, 2005·Molecular Endocrinology·Ronald N MargolisUNKNOWN NURSA Atlas Consortium
Jul 5, 2007·The Journal of Biological Chemistry·J Ignacio AguirreTeresita Bellido
Jan 24, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Ryeo-Eun GoKyung-Chul Choi
Jul 13, 2021·General and Comparative Endocrinology·Sheridan J C BakerGlen Van Der Kraak

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.