PMID: 6538502Mar 1, 1984Paper

Receptor-mediated antiproliferative effects of corticosteroids in Lewis lung tumors

European Journal of Cancer & Clinical Oncology
P G BraunschweigerL M Schiffer

Abstract

Dextran-coated charcoal competitive binding assays and Scatchard analysis revealed the presence of high-affinity, low capacity binding sites for dexamethasone in cytosol preparations from Lewis lung tumors. In vitro studies with live cells indicated approximately 9000 nuclear binding sites/cell for the ligand-receptor complex. In vivo inhibition of cell proliferation by dexamethasone, methylprednisolone and triamcinolone acetonide was found to be dose-dependent. Changes in the [3H]-TdR labeling index, mitotic index and saturable cytosol receptor sites after dexamethasone treatment in vivo suggested a dose-dependent G1 progression delay which, after cessation of dexamethasone treatments, was apparently reversible. Resumption of cell-cycle progression was characterized by synchronous progression through S-phase and correlated temporally with receptor site desaturation. In vivo studies indicated that the effectiveness of vincristine given after dexamethasone was highly sequence-dependent, with the most effective sequence interval being coincident with the interval of maximal S-phase cellularity. Other studies indicated sequential chemotherapy with dexamethasone, vincristine and 5-Fu could be effectively employed, following primary...Continue Reading

References

Feb 1, 1979·Journal of Cellular Physiology·J M HarmonE B Thompson
Jul 1, 1977·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·P G Braunschweiger, L M Schiffer
May 1, 1978·Endocrinology·P L BallardW H Douglas
Oct 1, 1977·Journal of the National Cancer Institute·P G BraunschweigerL M Schiffer
May 1, 1973·Journal of Applied Physiology·S H CarsonM E Avery

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Citations

Feb 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·F MauroM Spanò
Apr 1, 1993·International Journal of Cancer. Journal International Du Cancer·K A DromsD G Beer
Apr 21, 2018·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Christopher I McHughAnthony F Shields

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