Abstract
Toxic agents, particularly those that exert their actions with a great deal of specificity, sometimes act via receptors to which they bind with high affinity. Some examples of soluble intracellular receptors, which are important in mediating toxic responses, are discussed in this paper. The first example is the glucocorticoid receptor, which can act as a model for other receptors but is also involved in mediating toxicity associated effects such as apoptosis of lymphocytes as well as neuronal degeneration as a response to stress. Other examples discussed are the peroxisome proliferator activated receptor (PPAR) which is associated with hepatocarcinogenesis in rodents, and the dioxin receptor which is involved in a whole range of toxic effects. The final example given is an interesting mechanism for tissue specific accumulation of a metabolite of polychlorinated biphenyls.
References
May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M GöttlicherJ A Gustafsson
Sep 1, 1992·Carcinogenesis·M I KlemanJ A Gustafsson
Jul 13, 1990·Science·T HärdR Kaptein
Oct 18, 1990·Nature·I Issemann, S Green
Jun 1, 1986·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·J LundJ A Gustafsson
Nov 1, 1995·Nature Structural Biology·T HärdJ Lund
May 9, 1995·Proceedings of the National Academy of Sciences of the United States of America·M L WhitelawL Poellinger
Jun 1, 1995·Nature·W BourguetD Moras
Feb 28, 1995·Proceedings of the National Academy of Sciences of the United States of America·K Dahlman-WrightT Härd
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·K Dahlman-WrightA P Wright
Dec 14, 1993·Biochemical Pharmacology·M GöttlicherJ A Gustafsson
May 1, 1993·Molecular and Cellular Endocrinology·J KononenM Pelto-Huikko
Feb 1, 1997·Biochimie·J C CortonJ A Gustafsson
Aug 30, 2000·Biochemical Society Transactions·A E WallbergA P Wright
Feb 25, 2009·Molecular and Cellular Biology·Anna EhrlundEckardt Treuter
Citations
Oct 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·T Helleday
Dec 15, 2011·The Journal of Antibiotics·Jens BeckerEckhard Thines
Apr 23, 2005·SAR and QSAR in Environmental Research·M A LillA Vedani
Jul 23, 2005·International Journal of Toxicology·Daniel DesaulniersAlgis Yagminas
Apr 24, 2012·Toxicology and Applied Pharmacology·Angelo VedaniMartin Smieško
Aug 26, 2006·Basic & Clinical Pharmacology & Toxicology·Angelo VedaniMarkus A Lill
Dec 19, 2009·Alternatives to Laboratory Animals : ATLA·Angelo Vedani, Martin Smiesko