Receptor protein tyrosine kinase DDR is up-regulated by p53 protein

FEBS Letters
S SakumaH Abe

Abstract

We have previously reported on radiation-induction of ptk-3 in rat astrocyte culture [Sakuma et al. (1995) Radiat. Res. 143, 1-7]. Ptk-3 was considered to be a rat version of human DDR (discoidin domain receptor). We cloned and analyzed genomic DNA of the DDR and its promoter region. We discovered that the promoter region contained a consensus sequence of the p53 tumor suppressor binding site. Adenovirus-mediated p53 transfection induced a high level of DDR mRNA in SAOS2 human osteosarcoma cells. These results indicate that DDR is up-regulated by the p53 protein.

References

Apr 1, 1992·Nature Genetics·W S el-DeiryB Vogelstein
Feb 1, 1992·British Journal of Cancer·N ChandarJ Novak
Feb 24, 1995·Cell·E M MiyashitaD A Thorley-Lawson
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·M P SánchezM Barbacid
Nov 19, 1993·Cell·W S el-DeiryB Vogelstein
Jun 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J D JohnsonW J Rutter
Dec 22, 1995·Science·T J HudsonE S Lander

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Citations

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Dec 17, 1998·Trends in Cell Biology·M E Lukashev, Z Werb
Jan 5, 2001·Alcoholism, Clinical and Experimental Research·J M LewohlR A Harris
Jul 1, 2005·Molecular and Cellular Biology·Motonobu OsadaDavid Sidransky
Apr 15, 2014·International Review of Cell and Molecular Biology·Birgit Leitinger
Feb 14, 2002·Osteoarthritis and Cartilage·S IslamT M Haqqi
Dec 9, 2014·Cell Cycle·Martin FischerKurt Engeland
May 10, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·F AlvesW F Vogel
Oct 19, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·H KamoharaT Yoshimura
Jun 3, 1999·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·W Vogel
Mar 25, 2014·Cancer Discovery·Emily PowellHelen Piwnica-Worms
Jan 10, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Karmele ValenciaFernando Lecanda
Apr 22, 2006·Cellular Signalling·Wolfgang F VogelCaroline E Ford

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