PMID: 37127Mar 1, 1979

Receptor substances of brain mitochondria sensitive to neuromediators

Fiziologicheskiĭ zhurnal SSSR imeni I. M. Sechenova
A I Balakleevskiĭ, F I Viskmont


The action of some neurotransmitters and their derivatives on succinate dehydrogenase and cytochrome oxidase of rat brain mitochondria was studied in vitro. Alpha--adrenoreceptor blocking agents phentolamine and dibenzyline abolished the inhibitory action of the native forms of catecholamines (norepinephrine, epinephrine, isoproterenol) on the enzymatic activity under study. Relationships among catecholamines, cyclic 3',5'--AMP, and cortisone in their influence on these enzymes were studied. The data obtained indicate the existence of alpha--type adrenoreceptors in the brain mitochondria which can be responsible for the regulatory influences of catecholamines on functional activity of mitochondria.

Related Concepts

Cytochrome C Oxidase
Cytochrome c Oxidase Subunit VIa
Enzymes, antithrombotic
Succinate Dehydrogenase
Hormone Receptors, Cell Surface
Catecholamines Measurement

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