Receptor-targeting mechanisms of pain-causing toxins: How ow?

Toxicon : Official Journal of the International Society on Toxinology
Christopher J Bohlen, David Julius

Abstract

Venoms often target vital processes to cause paralysis or death, but many types of venom also elicit notoriously intense pain. While these pain-producing effects can result as a byproduct of generalized tissue trauma, there are now multiple examples of venom-derived toxins that target somatosensory nerve terminals in order to activate nociceptive (pain-sensing) neural pathways. Intriguingly, investigation of the venom components that are responsible for evoking pain has revealed novel roles and/or configurations of well-studied toxin motifs. This review serves to highlight pain-producing toxins that target the capsaicin receptor, TRPV1, or members of the acid-sensing ion channel family, and to discuss the utility of venom-derived multivalent and multimeric complexes.

References

May 23, 1979·Biochimica Et Biophysica Acta·R A Hendon, A T Tu
Sep 1, 1979·European Journal of Biochemistry·C BonH Fraenkel-Conrat
Mar 1, 1975·Pain·L A Chahl, E J Kirk
Nov 1, 1992·Revista Do Instituto De Medicina Tropical De São Paulo·P V Silveria, S de A Nishioka
Nov 1, 1992·Toxicon : Official Journal of the International Society on Toxinology·L D PossaniA M Brown
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·H SchweitzM Lazdunski
Jan 1, 1990·Toxicon : Official Journal of the International Society on Toxinology·F DucancelA Ménez
Apr 1, 1988·Journal of Medicinal Chemistry·P S PortogheseA E Takemori
Aug 1, 1988·Journal of Medicinal Chemistry·A F JoslynD J Triggle
Apr 1, 1987·Journal of Medicinal Chemistry·H Kizuka, R N Hanson
Jan 1, 1980·Neuroscience·O A Krishtal, V I Pidoplichko
Aug 1, 1993·Annals of Tropical Medicine and Parasitology·S A NishiokaL B Menzes
Jan 15, 1998·Toxicon : Official Journal of the International Society on Toxinology·B J Hawgood
Nov 5, 1999·Journal of Biomedical Science·C C Chang
Feb 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·T H SzetoG F King
Jun 1, 2000·The Journal of Biological Chemistry·P EscoubasM Lazdunski
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·E G Rowan
Feb 7, 2001·Molecular Biology and Evolution·S G ConticelloM Fainzilber
Feb 13, 2001·Gene·D Kordis, F Gubensek
May 19, 2001·The Journal of Biological Chemistry·N KedeiP M Blumberg
Dec 26, 2001·Journal of the American Chemical Society·J M GarganoW J Lees
Jul 3, 2002·The Journal of Biological Chemistry·Thomas VoetsBernd Nilius
Aug 9, 2002·The Journal of Biological Chemistry·Sasha LazeticJuha Punnonen
Feb 8, 2003·The EMBO Journal·J G J HoenderopR J M Bindels
Oct 4, 2003·Nature Reviews. Drug Discovery·Richard J Lewis, Maria L Garcia
Jan 1, 2004·The Journal of Biological Chemistry·Mette HesselagerPhilip K Ahring
Jan 13, 2004·Physiological Reviews·Heinrich Terlau, Baldomero M Olivera

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Citations

Dec 2, 2014·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Alejandro García-ArredondoJudith Sanchez-Rodriguez
Sep 22, 2015·Toxins·Md Abdul HakimRen Lai
Sep 2, 2015·Toxicon : Official Journal of the International Society on Toxinology·Julián FernándezBruno Lomonte
Mar 23, 2013·Scientific Reports·Jeet Kalia, Kenton J Swartz
Jan 24, 2015·Neuropharmacology·Anne Baron, Eric Lingueglia
Jun 5, 2013·Toxicon : Official Journal of the International Society on Toxinology·Jia-Wei MinBi-Wen Peng
Feb 21, 2013·Expert Opinion on Therapeutic Targets·János Szolcsányi, Erika Pintér
Apr 30, 2013·Toxicon : Official Journal of the International Society on Toxinology·Anne BaronEric Lingueglia
Dec 4, 2012·Toxicon : Official Journal of the International Society on Toxinology·David A Warrell
May 14, 2016·ELife·Feng ZhangKenton J Swartz
Aug 29, 2012·PloS One·Sandy Steffany PinedaGlenn F King
Feb 14, 2018·Current Opinion in Supportive and Palliative Care·Fernanda C CardosoRichard J Lewis
Nov 23, 2018·Proceedings of the National Academy of Sciences of the United States of America·Matan GeronAvi Priel
Feb 22, 2017·The Biochemical Journal·Juan J Calvete
Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Volker HerzigBryan G Fry
Mar 1, 2019·Toxins·Yossi MaatufAvi Priel
Jan 29, 2021·Frontiers in Immunology·José María GutiérrezGuillermo León
Jun 15, 2020·Biochemical Pharmacology·Volker HerzigGlenn F King
May 1, 2021·Biomedicines·Volker Herzig

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