Receptor-transporter interactions of canonical ATP-binding cassette import systems in prokaryotes

European Journal of Cell Biology
Erwin SchneiderWolfram Saenger

Abstract

ATP-binding cassette (ABC) transport systems mediate the translocation of solutes across biological membranes at the expense of ATP. They share a common modular architecture comprising two pore-forming transmembrane domains and two nucleotide binding domains. In prokaryotes, ABC transporters are involved in the uptake of a large variety of chemicals, including nutrients, osmoprotectants and signal molecules. In pathogenic bacteria, some ABC importers are virulence factors. Canonical ABC import systems require an additional component, a substrate-specific receptor or binding protein for function. Interaction of the liganded receptor with extracytoplasmic loop regions of the transmembrane domains initiate the transport cycle. In this review we summarize the current knowledge on receptor-transporter interplay provided by crystal structures as well as by biochemical and biophysical means. In particular, we focus on the maltose/maltodextrin transporter of enterobacteria and the transporters for positively charged amino acids from the thermophile Geobacillus stearothermophilus and Salmonella enterica serovar Typhimurium.

References

Jan 1, 1986·Annual Review of Biochemistry·G F Ames
Mar 1, 1995·Journal of Bacteriology·I C Sutcliffe, R R Russell
Apr 8, 1998·Microbiology and Molecular Biology Reviews : MMBR·W Boos, H Shuman
Oct 9, 2002·EMBO Reports·Tiemen van der Heide, Bert Poolman
Oct 7, 2003·Molecular Cell·Jue ChenFlorante A Quiocho
Nov 12, 2003·The EMBO Journal·Esther Biemans-Oldehinkel, Bert Poolman
Jan 2, 2004·Journal of Bacteriology·Takashi KoyanagiHidehiko Kumagai
Dec 6, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gang LuJue Chen
Dec 15, 2005·The Journal of Biological Chemistry·Martin L DausErwin Schneider
Dec 27, 2005·FEBS Letters·Esther Biemans-OldehinkelBert Poolman
Mar 17, 2006·Naunyn-Schmiedeberg's Archives of Pharmacology·Christine OswaldLutz Schmitt
Feb 27, 2007·Nature·Kaspar HollensteinKaspar P Locher
Jan 17, 2008·BMC Evolutionary Biology·Kenneth M NollDhaval M Nanavati
Jun 7, 2008·Microbiology and Molecular Biology Reviews : MMBR·Amy L DavidsonJue Chen
Aug 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Cedric OrelleAmy L Davidson
Oct 30, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Kaspar P Locher
Feb 24, 2009·Nature Reviews. Molecular Cell Biology·Douglas C ReesOded Lewinson
Mar 3, 2009·Molecular Cell·Dheeraj KhareJue Chen
Apr 14, 2009·Journal of Molecular Biology·Justin LecherErhard Bremer
Jan 26, 2010·Chembiochem : a European Journal of Chemical Biology·Vivien LangeHartmut Oschkinat
Feb 23, 2010·Nature Structural & Molecular Biology·Oded LewinsonDouglas C Rees
Mar 17, 2010·Biochimica Et Biophysica Acta·Viola EckeyErwin Schneider
Apr 24, 2010·FEBS Letters·Ronnie P-A BerntssonBert Poolman

❮ Previous
Next ❯

Citations

Feb 22, 2012·European Journal of Cell Biology·Haydar BulutArdeschir Vahedi-Faridi
Sep 17, 2013·The Journal of Biological Chemistry·Byron C H ChuHans J Vogel
Jul 1, 2020·ELife·Ljuvica R KolichDamian C Ekiert
Jun 20, 2018·Nature Chemical Biology·Min YangOded Lewinson
Sep 22, 2016·The Journal of Physical Chemistry. C, Nanomaterials and Interfaces·Lauren M BrowningXiao-Hong Nancy Xu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.