Receptor usage and cell entry of porcine epidemic diarrhea coronavirus

Journal of Virology
Chang LiuFang Li

Abstract

Porcine epidemic diarrhea coronavirus (PEDV) has significantly damaged America's pork industry. Here we investigate the receptor usage and cell entry of PEDV. PEDV recognizes protein receptor aminopeptidase N from pig and human and sugar coreceptor N-acetylneuraminic acid. Moreover, PEDV infects cells from pig, human, monkey, and bat. These results support the idea of bats as an evolutionary origin for PEDV, implicate PEDV as a potential threat to other species, and suggest antiviral strategies to control its spread.

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Citations

May 24, 2016·Virus Research·Samaporn TeeravechyanAnan Jongkaewwattana
Jun 19, 2016·Virus Research·Wentao LiBerend-Jan Bosch
Sep 18, 2016·Virus Research·Bhudipa ChoudhuryFalko Steinbach
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Dec 13, 2019·Journal of Virology·Yushun WanFang Li
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Junwei ZhouShaobo Xiao
Oct 13, 2016·The Journal of Biological Chemistry·Chang LiuFang Li
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