PMID: 6172041Oct 1, 1981Paper

Receptors and effectors in hormone action on the kidney

The American Journal of Physiology
I S Edelman

Abstract

An analysis is presented of the similarities and differences in receptor-effector relationships in the actions of aldosterone and triiodothyronine on the kidney. Both agents augment tubular reabsorption of sodium at different sites in the nephron. Aldosterone acts primarily distally and triiodothyronine, primarily proximally. In both cases, the respective hormone-receptor complexes associate with target cell chromatin and modulate the abundance of specific coding by mRNAs for regulatory proteins. The quantitative relationships between nuclear-receptor occupancy and responses were analyzed by fractional plots in a bounded domain. When applied to the toad bladder, this analysis revealed a parabolic dependence of the increase in transepithelial Na+ transport on the abundance of nuclear of the increase in transepithelial Na+ transport on the abundance of nuclear aldosterone-receptor complexes. In contrast, four independent response parameters (QO2, QO2(t), Na-K-ATPase, alpha-glycerophosphate dehydrogenase) exhibited a hyperbolic dependence on nuclear abundance of T3 in the rat kidney. The observed cosaturation of nuclear occupancy and responses in both systems, for both hormones, implies that the respective high-affinity binding si...Continue Reading

Citations

Oct 22, 2002·American Journal of Physiology. Renal Physiology·Tae-Hwan KwonSøren Nielsen
Oct 21, 2011·American Journal of Physiology. Renal Physiology·Gustavo Frindt, Lawrence G Palmer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bladder Carcinoma In Situ

Bladder Carcinoma In Situ is a superficial bladder cancer that occurs on the surface layer of the bladder. Discover the latest research on this precancerous condition in this feed.